Berberis vulgaris 302 claims

species · family Berberidaceae · green plant · NCBI Taxonomy ↗

Common name: common barberry — Also written in claims: seedless barberry · common barberry · B . hispanica · B. hispanica · Berberis hispanica

Listed here with its subspecies, varieties and cultivar groups: Berberis vulgaris subsp. australis (6 claims)

21 spellings

Questions studied on this organism3 questions2 papers

Berberis vulgarisgailhampshire from Cradley, Malvern, U.K · CC BY 2.0 · Wikimedia Commons ↗

302 claims

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Observationobservedoriginal resultmeasured

Claim · model-written summary

Berberis vulgaris followed with UV 0.65 and RFC 0.63.

Taxon: Berberis vulgarisBerberis vulgarise0
Outcome: UVe0
Value: UV = 0.65, RFC = 0.63e0

Verbatim

e0
“Berberis vulgaris (UV = 0.65, RFC = 0.63)”
✓ located verbatim in the source · abstract, characters 1269–1310

Title

Traditional knowledge and utilization of wild edible plants in Swat district, Pakistan: implications for nutrition and food security

Shujat Ali; Salahud Din; Sayed Afzal Shah; et al. Journal of Ethnobiology and Ethnomedicine 2026. doi:10.1186/s13002-026-00850-3

Other claims from this paper (19)

Observation The survey documented 175 wild edible plant species from 72 families.
Observation Herbs accounted for 62.3% of documented plants.
Observation Shrubs accounted for 20.6% of documented plants.
Observation Trees accounted for 16% of documented plants.
Observation Climbers accounted for 1.1% of documented plants.
Observation Young shoots were used by 41.7%.
Observation Fruits were used by 30.6%.
Observation Leaves were used by 13.9%.
Observation Vegetable use accounted for 37%.
Observation Fruit use accounted for 39%.
Observation Raw food use accounted for 14%.
Observation Tea or flavoring use accounted for 5%.
Observation Sauce or chutney use accounted for 2%.
Observation Oil use accounted for 2%.
Observation Berberis lycium had the highest cultural importance, with UV 0.813 and RFC 0.75.
Observation Chenopodium album followed with UV 0.68 and RFC 0.63.
Observation Novel uses were high for 22%, moderate for 23%, and low for 55% of 115 species.
Observation Twenty-seven species were marketed locally at 0.09 to 1.74 dollars per kg.
Observation The assessment identified three endangered and three vulnerable species.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Berberis vulgaris extracted with water had the highest % R score.

Taxon: Berberis vulgaris L.Berberis vulgarise7
Treatment: exacted with watere7
Outcome: % Re7
Direction: highest scoree7

Verbatim

e7
“The highest score for % R, %Y and % B was obtained for Berberis vulgaris L. exacted with water, for Berberis integerrima L. extracted with ethanol and Berberis integerrima L. extracted with water, respectively”
✓ located verbatim in the source · abstract, characters 1781–1990

Title

Evaluation of bioactive components and antioxidant activities of Rose canina L., Viburnum opulus L., Berberis vulgaris L. and Berberis integerrima L. subjected to different extraction methods

Saeid Chobdar Rahim; Zülal Günay; Hatice Kalkan Yıldırım Croatian Journal of Food Science and Technology 2025. doi:10.17508/cjfst.2025.17.1.02

Other claims from this paper (12)

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: Melatonine1
Outcome: total alkaloide1
Direction: alterede1
Value: 1.63 mg g −1 FWe1
Qualifier: the highest level observed at 50 µMe1

Not reportedComparator

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e1
“Melatonin altered total alkaloid and berberine contents, with the highest level observed at 50 µM (1.63 mg g −1 FW and 60.63 µg g −1 DW, respectively)”
✓ located verbatim in the source · abstract, characters 594–744

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: Melatonine1
Outcome: berberine contentse1
Direction: alterede1
Value: 60.63 µg g −1 DWe1
Qualifier: the highest level observed at 50 µMe1

Not reportedComparator

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e1
“Melatonin altered total alkaloid and berberine contents, with the highest level observed at 50 µM (1.63 mg g −1 FW and 60.63 µg g −1 DW, respectively)”
✓ located verbatim in the source · abstract, characters 594–744

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Intervention effectobservedoriginal resultsignificant (as stated)measured

Claim · model-written summary

Melatonin significantly increased tyrosine level, a precursor to berberine.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: Melatonine2
Outcome: tyrosine (Tyr) levele2
Direction: increasede2

Not reportedComparator

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e2
“Melatonin also significantly increased tyrosine (Tyr) level, a precursor to berberine”
✓ located verbatim in the source · abstract, characters 746–831

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Exogenous melatonin enhanced phenylalanine content and PAL activity.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: exogenous melatonine3
Outcome: phenylalanine (Phe) content and PAL activitye3
Direction: enhancede3

Not reportedComparator

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e3
“phenylalanine (Phe) content and PAL activity enhanced in response to exogenous melatonin”
✓ located verbatim in the source · abstract, characters 842–930

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: exogenous melatonine3
Outcome: cinnamic acid and coumaric acide4
Direction: accumulatione4
Qualifier: dose-dependente4

Not reportedComparator

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e3
“phenylalanine (Phe) content and PAL activity enhanced in response to exogenous melatonin”
✓ located verbatim in the source · abstract, characters 842–930

e4
“leading to a dose-dependent cinnamic acid and coumaric acid accumulation”
✓ located verbatim in the source · abstract, characters 932–1004

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Melatonin influences the individual flavonoid profile in B. vulgaris cultures.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: melatonine5
Outcome: individual flavonoids profilee5

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e5
“The HPLC results revealed that melatonin also influences the individual flavonoids profile”
✓ located verbatim in the source · abstract, characters 1006–1096

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: melatonine5
Outcome: catechine6
Direction: highere6
Value: 19.59e6
Comparator: control levelse6

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e5
“The HPLC results revealed that melatonin also influences the individual flavonoids profile”
✓ located verbatim in the source · abstract, characters 1006–1096

e6
“The highest increase was detected in catechin, kaempferol, and myricetin contents, which were 19.59, 14.73, and 9.26 times higher than the control levels, respectively”
✓ located verbatim in the source · abstract, characters 1098–1265

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Kaempferol content was 14.73 times higher than the control levels in melatonin-treated cultures.

Taxon: Berberis vulgaris L.Berberis vulgarist0
Treatment: melatonine5
Outcome: kaempferole6
Direction: highere6
Value: 14.73e6
Comparator: control levelse6

Verbatim

t0
“Berberis vulgaris L. suspension cultures”
✓ located verbatim in the source · title, characters 110–150

e5
“The HPLC results revealed that melatonin also influences the individual flavonoids profile”
✓ located verbatim in the source · abstract, characters 1006–1096

e6
“The highest increase was detected in catechin, kaempferol, and myricetin contents, which were 19.59, 14.73, and 9.26 times higher than the control levels, respectively”
✓ located verbatim in the source · abstract, characters 1098–1265

Title

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Seyedeh Hanieh Zeidi; Mohsen Sharifi; Elaheh Samari; et al. Scientific Reports 2025. doi:10.1038/s41598-025-17203-x

Other claims from this paper (13)

Intervention effect Melatonin altered total alkaloid content, which was highest at 50 µM at 1.63 mg g −1 FW.
Intervention effect Melatonin altered berberine content, which was highest at 50 µM at 60.63 µg g −1 DW.
Intervention effect Melatonin significantly increased tyrosine level, a precursor to berberine.
Intervention effect Exogenous melatonin enhanced phenylalanine content and PAL activity.
Intervention effect Exogenous melatonin dose-dependently increased cinnamic acid and coumaric acid accumulation.
Observation Melatonin influences the individual flavonoid profile in B. vulgaris cultures.
Intervention effect Catechin content was 19.59 times higher than the control levels in melatonin-treated cultures.
Intervention effect Myricetin content was 9.26 times higher than the control levels in melatonin-treated cultures.
Intervention effect Melatonin-treated cells had disturbed oxidative balance.
Intervention effect Melatonin-treated cells increased hydrogen peroxide and nitric oxide generation.
Observation Antioxidant enzymes SOD, POD and APX were activated in melatonin-treated B. vulgaris cells.
Association Ascorbic acid levels increased in melatonin-treated B. vulgaris cells.
Mechanism Melatonin may allocate tyrosine and phenylalanine towards berberine and phenolics accumulation, possibly by modulating oxidative status.