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Claim · model-written summary
The chalcone 2’,4’-dihydroxychalcone (4) had the lowest MIC, at or below 0.02 µM, against Saprolegnia parasitica.
- Taxon
- Adesmia balsamica
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Adesmia balsamicat0 - Interactor
- Saprolegnia parasiticaSaprolegnia parasiticae0pathogen
- Compound
- 2’,4’-dihydroxychalcone (4)e1
- Outcome
- MICe1
- Value
- ≤ 0.02 µMe1
Verbatim
t0“Flavonoids from Adesmia balsamica”
e0“in vitro against Saprolegnia parasitica and S. australis”
e1“Results identified 2’,4’-dihydroxychalcone (4) as the most potent compound, with high efficacy (MIC ≤ 0.02 µM) and achieving 100% inhibition of both mycelial growth and cell membrane lysis, supported by highly favourable binding energies (−7.95 kcal/mol)”
Title
Carmen Trujillo; Iván Montenegro; Evelyn Muñoz; et al. Natural Product Research 2026. doi:10.1080/14786419.2026.2655403
Other claims from this paper (7)
- Observation The chalcone 2’,4’-dihydroxychalcone (4) gave 100% inhibition of Saprolegnia mycelial growth and cell membrane lysis.
- Observation Docking of 2’,4’-dihydroxychalcone (4) gave a binding energy of −7.95 kcal/mol.
- Observation The prenylated flavanone glabranin (2) had significant activity against Saprolegnia, with MIC values as low as 0.04 µM.
- Observation Glabranin (2) caused up to 78 percent membrane damage in Saprolegnia.
- Observation Phytochemical analysis of the Adesmia balsamica exudate identified five known metabolites.
- Mechanism Chalcone 4 and flavanone 2 are the primary drivers of the Adesmia balsamica exudate bioactivity.
- Recommendation The authors position the flavonoids as promising candidates for developing new biopesticides against saprolegniosis.