Abstract
A mutation in the Arabidopsis gene STARIK leads to dwarfism and chlorosis of plants with an altered morphology of leaf and cell nuclei. We show that the STARIK gene encodes the mitochondrial ABC transporter Sta1 that belongs to a subfamily of Arabidopsis half-ABC transporters. The severity of the starik phenotype is suppressed by the ectopic expression of the STA2 homolog; thus, Sta1 function is partially redundant. Sta1 supports the maturation of cytosolic Fe/S protein in Deltaatm1 yeast, substituting for the ABC transporter Atm1p. Similar to Atm1p-deficient yeast, mitochondria of the starik mutant accumulated more nonheme, nonprotein iron than did wild-type organelles. We further show that plant mitochondria contain a putative l-cysteine desulfurase. Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.
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Claims 7
Claim · model-written summary
STARIK mutation caused dwarfism, chlorosis and altered leaf and nuclear morphology.
- Taxon
- Arabidopsis
Arabidopsise0 - Gene
- STARIKe0
- Outcome
- dwarfism and chlorosis of plants with an altered morphology of leaf and cell nucleie0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“A mutation in the Arabidopsis gene STARIK leads to dwarfism and chlorosis of plants with an altered morphology of leaf and cell nuclei”
Claim · model-written summary
STARIK encodes mitochondrial ABC transporter Sta1.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- STARIKe0
- Outcome
- mitochondrial ABC transporter Sta1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the STARIK gene encodes the mitochondrial ABC transporter Sta1”
t0“Arabidopsis”
Claim · model-written summary
Ectopic STA2 expression suppressed the starik phenotype.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- ectopic expression of the STA2 homologe0
- Gene
- STA2e0
- Outcome
- severity of the starik phenotypee0
- Direction
- suppressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The severity of the starik phenotype is suppressed by the ectopic expression of the STA2 homolog”
t0“Arabidopsis”
Claim · model-written summary
Sta1 supported cytosolic Fe/S protein maturation in Deltaatm1 yeast.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- Sta1e0
- Outcome
- maturation of cytosolic Fe/S protein in Deltaatm1 yeaste0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Sta1 supports the maturation of cytosolic Fe/S protein in Deltaatm1 yeast, substituting for the ABC transporter Atm1p”
t0“Arabidopsis”
Claim · model-written summary
Starik mitochondria accumulated more nonheme, nonprotein iron than wild type.
- Taxon
- ArabidopsisArabidopsist0
- Material
- starik mutante0
- Outcome
- nonheme, nonprotein irone0
- Direction
- moree0
- Comparator
- wild-type organellese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mitochondria of the starik mutant accumulated more nonheme, nonprotein iron than did wild-type organelles”
t0“Arabidopsis”
Claim · model-written summary
Plant mitochondria contained a putative l-cysteine desulfurase.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- l-cysteine desulfurasee0
- Outcome
- putative l-cysteine desulfurasee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“plant mitochondria contain a putative l-cysteine desulfurase”
t0“Arabidopsis”
Claim · model-written summary
Authors inferred a conserved mitochondrial Fe/S biosynthesis pathway linked to iron homeostasis.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- Atm1p-like ABC transporterse0
- Outcome
- intracellular iron homeostasise0
- Qualifier
- evolutionarily conserved Fe/S cluster biosynthesis pathwaye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters”
t0“Arabidopsis”
The same questions in other papers
overexpression · disease · ArabidopsisPositive and negative results
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- negative
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