Abstract
The tomato gene Tm-2(2) encodes a coiled coil-nucleotide binding site-leucine rich repeat type resistance protein, which confers effective immune response against tobamoviruses by detecting the presence of viral movement proteins (MPs). Here we report that the N.benthamiana Heat shock protein 90 (Hsp90) specifically interacts with Tm-2(2). Silencing of Hsp90 compromised Tm-2(2)-mediated resistance against Tobacco mosaic virus (TMV) and reduced the steady-state levels of Tm-2(2) protein. In addition, we found that Hsp90 associates with SGT1 in yeast and in plant cells. These results suggest that Hsp90-SGT1 complex takes part in Tm-2(2)-mediated TMV resistance by functioning as chaperone to regulate Tm-2(2) stability.
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Claims 5
Claim · model-written summary
N.benthamiana Hsp90 specifically interacts with Tm-2(2).
Verbatim
e0“the N.benthamiana Heat shock protein 90 (Hsp90) specifically interacts with Tm-2(2)”
Claim · model-written summary
Silencing Hsp90 compromised Tm-2(2)-mediated resistance to TMV.
- Taxon
- N.benthamianae1
- Treatment
- Silencing of Hsp90e0
- Interactor
- Tobacco mosaic virus
Tobacco mosaic viruse0pathogen - Gene
- Hsp90e0
- Outcome
- Tm-2(2)-mediated resistance against Tobacco mosaic virus (TMV)e0
- Direction
- compromisede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Silencing of Hsp90 compromised Tm-2(2)-mediated resistance against Tobacco mosaic virus (TMV)”
e1“the N.benthamiana Heat shock protein 90 (Hsp90)”
Claim · model-written summary
Silencing Hsp90 reduced steady-state Tm-2(2) protein levels.
- Taxon
- N.benthamianae1
- Treatment
- Silencing of Hsp90e0
- Gene
- Tm-2(2) proteine0
- Outcome
- steady-state levels of Tm-2(2) proteine0
- Direction
- reducede0
Not reportedComparator
Verbatim
e0“Silencing of Hsp90 compromised Tm-2(2)-mediated resistance against Tobacco mosaic virus (TMV) and reduced the steady-state levels of Tm-2(2) protein”
e1“the N.benthamiana Heat shock protein 90 (Hsp90)”
Claim · model-written summary
Hsp90 associates with SGT1 in yeast and plant cells.
Verbatim
e0“Hsp90 associates with SGT1 in yeast and in plant cells”
e1“the N.benthamiana Heat shock protein 90 (Hsp90)”
Claim · model-written summary
The authors suggest the Hsp90-SGT1 complex regulates Tm-2(2) stability as a chaperone in TMV resistance.
- Taxon
- N.benthamianae1
- Interactor
- TMVTobacco mosaic viruse0pathogen
- Gene
- Tm-2(2)e0
- Outcome
- Tm-2(2)-mediated TMV resistancee0
- Qualifier
- functioning as chaperone to regulate Tm-2(2) stabilitye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Hsp90-SGT1 complex takes part in Tm-2(2)-mediated TMV resistance by functioning as chaperone to regulate Tm-2(2) stability”
e1“the N.benthamiana Heat shock protein 90 (Hsp90)”
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