Abstract
ATP-binding cassette (ABC) transporters hydrolyze ATP to transport a wide range of substrates. Fusarium graminearum is a major causal agent of Fusarium head blight, which is a severe disease in wheat worldwide. FgABCC9 (FG05_07325) encodes an ABC-C (ABC transporter family C) transporter in F. graminearum, which was highly expressed during the infection in wheat and was up-regulated by the plant defense hormone salicylic acid (SA) and the fungicide tebuconazole. The predicted tertiary structure of the FgABCC9 protein was consistent with the schematic of the ABC exporter. Deletion of FgABCC9 resulted in decreased mycelial growth, increased sensitivity to SA and tebuconazole, reduced accumulation of deoxynivalenol (DON), and less pathogenicity towards wheat. Re-introduction of a functional FgABCC9 gene into ΔFgABCC9 recovered the phenotypes of the wild type strain. Transgenic expression of FgABCC9 in Arabidopsis thaliana increased the accumulation of SA in its leaves without activating SA signaling, which suggests that FgABCC9 functions as an SA exporter. Taken together, FgABCC9 encodes an ABC exporter, which is critical for fungal exportation of SA, response to tebuconazole, mycelial growth, and pathogenicity towards wheat.
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Claims 12
Claim · model-written summary
FgABCC9 expression rose during wheat infection.
- Taxon
- F. graminearum
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=60)
Fusarium graminearume0 - Gene
- FgABCC9e0
- Outcome
- highly expressede0
- Setting
- wheate0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=500)
Verbatim
e0“FgABCC9 (FG05_07325) encodes an ABC-C (ABC transporter family C) transporter in F. graminearum, which was highly expressed during the infection in wheat”
Claim · model-written summary
SA up-regulated fungal FgABCC9 expression.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- salicylic acide0
- Gene
- FgABCC9e1
- Outcome
- up-regulatede0
- Direction
- up-regulatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“was up-regulated by the plant defense hormone salicylic acid (SA)”
t0“Fusarium graminearum”
e1“FgABCC9 (FG05_07325)”
Claim · model-written summary
Tebuconazole up-regulated fungal FgABCC9 expression.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- tebuconazolee0
- Gene
- FgABCC9e1
- Outcome
- up-regulatede0
- Direction
- up-regulatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“was up-regulated by the plant defense hormone salicylic acid (SA) and the fungicide tebuconazole”
t0“Fusarium graminearum”
e1“FgABCC9 (FG05_07325)”
Claim · model-written summary
Predicted FgABCC9 structure matched an ABC exporter schematic.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Gene
- FgABCC9e0
- Outcome
- predicted tertiary structuree0
- Comparator
- schematic of the ABC exportere0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The predicted tertiary structure of the FgABCC9 protein was consistent with the schematic of the ABC exporter.”
t0“Fusarium graminearum”
Claim · model-written summary
FgABCC9 deletion decreased fungal mycelial growth.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- Deletion of FgABCC9e0
- Gene
- FgABCC9e0
- Outcome
- mycelial growthe0
- Direction
- decreasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Deletion of FgABCC9 resulted in decreased mycelial growth”
t0“Fusarium graminearum”
Claim · model-written summary
FgABCC9 deletion increased fungal sensitivity to SA and tebuconazole.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- Deletion of FgABCC9e0
- Outcome
- sensitivity to SA and tebuconazolee0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Deletion of FgABCC9 resulted in decreased mycelial growth, increased sensitivity to SA and tebuconazole”
t0“Fusarium graminearum”
Claim · model-written summary
FgABCC9 deletion reduced DON accumulation.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- Deletion of FgABCC9e1
- Outcome
- accumulation of deoxynivalenol (DON)e0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“reduced accumulation of deoxynivalenol (DON)”
e1“Deletion of FgABCC9”
t0“Fusarium graminearum”
Claim · model-written summary
FgABCC9 deletion reduced pathogenicity toward wheat.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- Deletion of FgABCC9e1
- Interactor
- wheat
Triticum aestivume0host - Outcome
- pathogenicity towards wheate0
- Direction
- lesse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“less pathogenicity towards wheat”
e1“Deletion of FgABCC9”
t0“Fusarium graminearum”
Claim · model-written summary
Reintroducing FgABCC9 restored wild-type phenotypes.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Treatment
- Re-introduction of a functional FgABCC9 gene into ΔFgABCC9e0
- Outcome
- phenotypese0
- Direction
- recoverede0
- Comparator
- wild type straine0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Re-introduction of a functional FgABCC9 gene into ΔFgABCC9 recovered the phenotypes of the wild type strain.”
t0“Fusarium graminearum”
Claim · model-written summary
Transgenic FgABCC9 expression increased leaf SA accumulation in Arabidopsis.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae0 - Organ / stage
- leavese0
- Treatment
- Transgenic expression of FgABCC9e0
- Outcome
- accumulation of SAe0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Transgenic expression of FgABCC9 in Arabidopsis thaliana increased the accumulation of SA in its leaves”
Claim · model-written summary
Transgenic FgABCC9 expression did not activate SA signaling in Arabidopsis.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0
- Treatment
- Transgenic expression of FgABCC9e0
- Outcome
- SA signalinge0
- Direction
- without activatinge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Transgenic expression of FgABCC9 in Arabidopsis thaliana increased the accumulation of SA in its leaves without activating SA signaling”
Claim · model-written summary
The authors infer FgABCC9 functions as an SA exporter.
- Taxon
- Fusarium graminearumFusarium graminearumt0
- Gene
- FgABCC9e0
- Outcome
- SA exportere0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“which suggests that FgABCC9 functions as an SA exporter”
t0“Fusarium graminearum”
The same questions in other papers
loss of function · Triticum aestivum · Fusarium graminearumPositive and negative results
1 paper in the same direction as this paper · 1 in the opposite direction
- positive
- negative
loss of function · disease · Fusarium graminearumPositive and negative results
2 papers in the same direction as this paper · 2 in the opposite direction
- positive
- positive
- negative
1 paper more in this group
See all 5 papers →loss of function · molecular: metabolites · Fusarium graminearumResults agree
1 paper in the same direction as this paper
- no effect
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.