Search claims · PlantClaims

Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

The authors infer cAPX suppression reduces H2O2 scavenging and enables H2O2 accumulation and faster PCD.

Taxon: TobaccoNicotiana tabacumt0
Compound: H2O2e0
Outcome: acceleration of PCDe0
Direction: acceleratione0
Qualifier: reduction in the capability of cells to scavenge H2O2e0

Verbatim

e0
“This suppression is likely to contribute to a reduction in the capability of cells to scavenge H2O2, which in turn enables the accumulation of H2O2 and the acceleration of PCD”
✓ located verbatim in the source · abstract, characters 1228–1403

t0
“Tobacco”
✓ located verbatim in the source · title, characters 127–134

Title

Post-Transcriptional Suppression of Cytosolic Ascorbate Peroxidase Expression during Pathogen-Induced Programmed Cell Death in Tobacco

Ron Mittler; Xuqiao Feng; Mira Cohen The Plant Cell 1998. doi:10.1105/tpc.10.3.461

Other claims from this paper (7)

Observation During viral induced PCD in tobacco, cAPX expression was suppressed after transcription.
Observation cAPX transcripts increased during PCD.
Observation cAPX protein levels declined during PCD.
Observation In vivo labeling and immunoprecipitation indicated inhibited cAPX protein synthesis.
Observation cAPX transcripts remained associated with polysomes during PCD.
Observation No cAPX protein was detected after in vitro polysome run off assays.
Mechanism The authors suggest cAPX suppression may occur at translation elongation.

Observationobservedoriginal resultnegativemeasured

Claim · model-written summary

Anti-PCD signalling cascades were inhibited during peroxide-induced programmed cell death.

Taxon: tobaccoNicotiana tabacumt0
Outcome: anti-PCD signalling cascadese0
Direction: inhibitede0

Verbatim

e0
“The antioxidant defence system and the anti-PCD signalling cascades are inhibited.”
✓ located verbatim in the source · abstract, characters 872–954

t0
“tobacco Bright Yellow-2 cells”
✓ located verbatim in the source · title, characters 24–53

Title

The soluble proteome of tobacco Bright Yellow-2 cells undergoing H2O2-induced programmed cell death

C. Vannini; M. Marsoni; C. Cantara; et al. Journal of Experimental Botany 2012. doi:10.1093/jxb/ers031

Other claims from this paper (8)

Observationobservedoriginal resultnegativemeasured

Claim · model-written summary

During viral induced PCD in tobacco, cAPX expression was suppressed after transcription.

Taxon: tobaccoNicotiana tabacume0
Gene: cytosolic ascorbate peroxidase (cAPX)e0
Outcome: expression of cytosolic ascorbate peroxidase (cAPX)e0
Direction: suppressede0
Qualifier: viral-induced PCDe0

Verbatim

e0
“during viral-induced PCD in tobacco, the expression of cytosolic ascorbate peroxidase (cAPX), a key H2O2 detoxifying enzyme, is post-transcriptionally suppressed”
✓ located verbatim in the source · abstract, characters 451–612

Title

Post-Transcriptional Suppression of Cytosolic Ascorbate Peroxidase Expression during Pathogen-Induced Programmed Cell Death in Tobacco

Ron Mittler; Xuqiao Feng; Mira Cohen The Plant Cell 1998. doi:10.1105/tpc.10.3.461

Other claims from this paper (7)

Observation cAPX transcripts increased during PCD.
Observation cAPX protein levels declined during PCD.
Observation In vivo labeling and immunoprecipitation indicated inhibited cAPX protein synthesis.
Observation cAPX transcripts remained associated with polysomes during PCD.
Observation No cAPX protein was detected after in vitro polysome run off assays.
Mechanism The authors suggest cAPX suppression may occur at translation elongation.
Mechanism The authors infer cAPX suppression reduces H2O2 scavenging and enables H2O2 accumulation and faster PCD.

Mechanismobservedoriginal resultmeasured

Claim · model-written summary

Cobalt-induced initial H2O2 production may stimulate HO-1 expression.

Taxon: WheatTriticum aestivumt0
Gene: HO-1e0
Compound: H2O2e0
Outcome: stimulation of HO-1 expressione0

Verbatim

e0
“The stimulation of HO-1 expression, and alleviation of PCD might be caused by the initial H2O2 production induced by cobalt.”
✓ located verbatim in the source · abstract, characters 706–830

t0
“Wheat”
✓ located verbatim in the source · title, characters 54–59

Title

Cobalt Alleviates GA-Induced Programmed Cell Death in Wheat Aleurone Layers via the Regulation of H2O2 Production and Heme Oxygenase-1 Expression

Mingzhu Wu; Jiale Li; Fangquan Wang; et al. International Journal of Molecular Sciences 2014. doi:10.3390/ijms151121155

Other claims from this paper (9)

Intervention effect Cobalt delayed GA-induced programmed cell death in wheat aleurone layers.
Intervention effect Carbon monoxide pretreatment produced a similar delay of cell death.
Intervention effect Bilirubin pretreatment produced a similar delay of cell death.
Mechanism Increased HO-1 expression contributed to cobalt alleviation of cell death.
Intervention effect ZnPPIX substantially prevented cobalt-induced increases in HO-1 activity.
Intervention effect ZnPPIX substantially prevented cobalt-induced alleviation of cell death.
Mechanism Cobalt-induced initial H2O2 production may alleviate cell death.
Observation Cobalt-induced SOD, CAT and APX expression and activities were consistent with H2O2 accumulation during GA treatment.
Intervention effect ZnPPIX differentially blocked cobalt responses.

Mechanismobservedoriginal resultmeasured

Claim · model-written summary

Increased HO-1 expression contributed to cobalt alleviation of cell death.

Taxon: WheatTriticum aestivumt0
Treatment: cobalte0
Gene: HO-1e0
Outcome: alleviation of PCDe0

Verbatim

e0
“increased HO-1 expression played a role in the cobalt-induced alleviation of PCD”
✓ located verbatim in the source · abstract, characters 444–524

t0
“Wheat”
✓ located verbatim in the source · title, characters 54–59

Title

Cobalt Alleviates GA-Induced Programmed Cell Death in Wheat Aleurone Layers via the Regulation of H2O2 Production and Heme Oxygenase-1 Expression

Mingzhu Wu; Jiale Li; Fangquan Wang; et al. International Journal of Molecular Sciences 2014. doi:10.3390/ijms151121155

Other claims from this paper (9)

Intervention effect Cobalt delayed GA-induced programmed cell death in wheat aleurone layers.
Intervention effect Carbon monoxide pretreatment produced a similar delay of cell death.
Intervention effect Bilirubin pretreatment produced a similar delay of cell death.
Intervention effect ZnPPIX substantially prevented cobalt-induced increases in HO-1 activity.
Intervention effect ZnPPIX substantially prevented cobalt-induced alleviation of cell death.
Mechanism Cobalt-induced initial H2O2 production may stimulate HO-1 expression.
Mechanism Cobalt-induced initial H2O2 production may alleviate cell death.
Observation Cobalt-induced SOD, CAT and APX expression and activities were consistent with H2O2 accumulation during GA treatment.
Intervention effect ZnPPIX differentially blocked cobalt responses.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Fifteen proteins had differential expression resembling the pattern previously seen in heat shock induced cell death.

Taxon: tobaccoNicotiana tabacumt0
Outcome: differentially expressed proteinse0
Value: Fifteene0
Comparator: TBY-2 cells undergoing heat shock-induced PCDe0

Verbatim

e0
“Fifteen differentially expressed proteins showed an expression pattern similar to that previously observed in TBY-2 cells undergoing heat shock-induced PCD.”
✓ located verbatim in the source · abstract, characters 1016–1172

t0
“tobacco Bright Yellow-2 cells”
✓ located verbatim in the source · title, characters 24–53

Title

The soluble proteome of tobacco Bright Yellow-2 cells undergoing H2O2-induced programmed cell death

C. Vannini; M. Marsoni; C. Cantara; et al. Journal of Experimental Botany 2012. doi:10.1093/jxb/ers031

Other claims from this paper (8)

Intervention effect Hydrogen peroxide induced programmed cell death in tobacco Bright Yellow-2 cultures.
Intervention effect Hydrogen peroxide treatment caused early down-regulation of several redox hub elements.
Intervention effect Hydrogen peroxide treatment inhibited the protein repair-degradation system.
Observation Homeostatic response protein expression patterns, particularly metabolism-related proteins, were altered.
Observation Cytoskeleton protein abundance changed during programmed cell death.
Observation Tobacco cells undergoing peroxide-induced programmed cell death failed to cope with oxidative stress.
Observation The antioxidant defence system was inhibited during peroxide-induced programmed cell death.
Observation Anti-PCD signalling cascades were inhibited during peroxide-induced programmed cell death.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Microarray analysis of AT-induced cell death revealed a set of new H2O2-responsive genes highly regulated in a common fashion across types of programmed cell death.

Taxon: Arabidopsis thalianaArabidopsis thalianae0
Outcome: a set of new H(2)O(2)-responsive genese1

Verbatim

e0
“Arabidopsis thaliana”
✓ located verbatim in the source · abstract, characters 284–304

e1
“Microarray analysis with a DNA chip representing 21500 genes and subsequent comparison with other PCD-related expression studies revealed a set of new H(2)O(2)-responsive genes that were highly regulated in a common fashion during different types of PCD”
✓ located verbatim in the source · abstract, characters 481–734

Title

Hydrogen Peroxide-induced Cell Death in Arabidopsis: Transcriptional and Mutant Analysis Reveals a Role of an Oxoglutarate-dependent Dioxygenase Gene in the Cell Death Process

Tsanko Gechev; Ivan Minkov; Jacques Hille IUBMB Life 2005. doi:10.1080/15216540500090793

Other claims from this paper (4)

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

ZnPPIX substantially prevented cobalt-induced increases in HO-1 activity.

Taxon: WheatTriticum aestivumt0
Treatment: zinc protoporphyrin-IX (ZnPPIX)e0
Gene: HO-1e0
Outcome: HO-1 activitye0
Direction: preventede0

Not reportedComparator

Verbatim

e0
“The application of HO-1-specific inhibitor, zinc protoporphyrin-IX (ZnPPIX), substantially prevented the increases of HO-1 activity and the alleviation of PCD triggered by cobalt.”
✓ located verbatim in the source · abstract, characters 526–705

t0
“Wheat”
✓ located verbatim in the source · title, characters 54–59

Title

Cobalt Alleviates GA-Induced Programmed Cell Death in Wheat Aleurone Layers via the Regulation of H2O2 Production and Heme Oxygenase-1 Expression

Mingzhu Wu; Jiale Li; Fangquan Wang; et al. International Journal of Molecular Sciences 2014. doi:10.3390/ijms151121155

Other claims from this paper (9)

Intervention effect Cobalt delayed GA-induced programmed cell death in wheat aleurone layers.
Intervention effect Carbon monoxide pretreatment produced a similar delay of cell death.
Intervention effect Bilirubin pretreatment produced a similar delay of cell death.
Mechanism Increased HO-1 expression contributed to cobalt alleviation of cell death.
Intervention effect ZnPPIX substantially prevented cobalt-induced alleviation of cell death.
Mechanism Cobalt-induced initial H2O2 production may stimulate HO-1 expression.
Mechanism Cobalt-induced initial H2O2 production may alleviate cell death.
Observation Cobalt-induced SOD, CAT and APX expression and activities were consistent with H2O2 accumulation during GA treatment.
Intervention effect ZnPPIX differentially blocked cobalt responses.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Cytoskeleton protein abundance changed during programmed cell death.

Taxon: tobaccoNicotiana tabacumt0
Outcome: abundance of several cytoskeleton proteinse0

Verbatim

e0
“The changes in abundance of several cytoskeleton proteins confirmed the active role of the cytoskeleton in PCD signalling.”
✓ located verbatim in the source · abstract, characters 679–801

t0
“tobacco Bright Yellow-2 cells”
✓ located verbatim in the source · title, characters 24–53

Title

The soluble proteome of tobacco Bright Yellow-2 cells undergoing H2O2-induced programmed cell death

C. Vannini; M. Marsoni; C. Cantara; et al. Journal of Experimental Botany 2012. doi:10.1093/jxb/ers031

Other claims from this paper (8)

“H2O2-induced PCD”

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