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Molecular Characterization of a Family of Tandemly Repeated DNA Sequences, TR-1, in Heterochromatic Knobs of Maize and Its Relatives 5

Show all 5 →
Mechanismhypothesisoriginal resultbasis n/a

Claim · model-written summary

B' may have originated from B through lateral amplification accompanied by base-pair changes (author interpretation).

Taxon
maizeZea mayse2
Outcome
B'e4
Qualifier
originate from B through lateral amplification accompanied by base-pair changese4

Verbatim

e2

“we isolated 59 clones belonging to the TR-1 family from maize and teosinte”

✓ located verbatim in the source · abstract, characters 103–177
e4

“B' may originate from B through lateral amplification accompanied by base-pair changes”

✓ located verbatim in the source · abstract, characters 671–757

Title

Molecular Characterization of a Family of Tandemly Repeated DNA Sequences, TR-1, in Heterochromatic Knobs of Maize and Its Relatives

F C Hsu; C J Wang; C M Chen; et al. Genetics 2003. doi:10.1093/genetics/164.3.1087

Other claims from this paper (8)
Mechanismhypothesisoriginal resultbasis n/a

Claim · model-written summary

The B component may have evolved from the 180-bp knob repeat through mutations during evolution (author interpretation).

Taxon
maizeZea mayse2
Outcome
B componente3
Qualifier
as a result of mutations during evolutione3

Verbatim

e2

“we isolated 59 clones belonging to the TR-1 family from maize and teosinte”

✓ located verbatim in the source · abstract, characters 103–177
e3

“the B component may evolve from the 180-bp knob repeat as a result of mutations during evolution”

✓ located verbatim in the source · abstract, characters 569–665

Title

Molecular Characterization of a Family of Tandemly Repeated DNA Sequences, TR-1, in Heterochromatic Knobs of Maize and Its Relatives

F C Hsu; C J Wang; C M Chen; et al. Genetics 2003. doi:10.1093/genetics/164.3.1087

Other claims from this paper (8)
Mechanismhypothesisoriginal resultbasis n/a

Claim · model-written summary

C plus A may be a single sequence added to B and B', probably via nonhomologous recombination (author interpretation).

Taxon
maizeZea mayse2
Outcome
C plus Ae5
Qualifier
probably via nonhomologous recombinatione5

Verbatim

e2

“we isolated 59 clones belonging to the TR-1 family from maize and teosinte”

✓ located verbatim in the source · abstract, characters 103–177
e5

“C plus A may be a single sequence that is added to B and B', probably via nonhomologous recombination”

✓ located verbatim in the source · abstract, characters 763–864

Title

Molecular Characterization of a Family of Tandemly Repeated DNA Sequences, TR-1, in Heterochromatic Knobs of Maize and Its Relatives

F C Hsu; C J Wang; C M Chen; et al. Genetics 2003. doi:10.1093/genetics/164.3.1087

Other claims from this paper (8)

Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome 4

Show all 4 →
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Transposition may influence knob evolution.

Taxon
maizeZea mayst0
Outcome
evolution of knobse0
Qualifier
transpositione0

Not reportedDirection

Verbatim

e0

“environmental factors and transposition may play a role in the evolution of knobs.”

✓ located verbatim in the source · abstract, characters 1122–1204
t0

“Maize”

✓ located verbatim in the source · title, characters 48–53

Title

Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome

Edward S Buckler; Tara L Phelps-Durr; Carlyn S Keith Buckler; et al. Genetics 1999. doi:10.1093/genetics/153.1.415

Other claims from this paper (6)
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Environmental factors may influence knob evolution.

Taxon
maizeZea mayst0
Outcome
evolution of knobse0
Qualifier
environmental factorse0

Not reportedDirection

Verbatim

e0

“environmental factors and transposition may play a role in the evolution of knobs.”

✓ located verbatim in the source · abstract, characters 1122–1204
t0

“Maize”

✓ located verbatim in the source · title, characters 48–53

Title

Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome

Edward S Buckler; Tara L Phelps-Durr; Carlyn S Keith Buckler; et al. Genetics 1999. doi:10.1093/genetics/153.1.415

Other claims from this paper (6)
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Authors propose meiotic drive can cause rapid genome structural and diversity change.

Taxon
MaizeZea mayst0
Outcome
changes in genome structure and diversitye0
Qualifier
Meiotic drivee0

Verbatim

e0

“Meiotic drive may be a major force of genome evolution, allowing revolutionary changes in genome structure and diversity over short evolutionary periods.”

✓ located verbatim in the source · abstract, characters 1432–1585
t0

“Maize”

✓ located verbatim in the source · title, characters 48–53

Title

Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome

Edward S Buckler; Tara L Phelps-Durr; Carlyn S Keith Buckler; et al. Genetics 1999. doi:10.1093/genetics/153.1.415

Other claims from this paper (6)

Independently Regulated Neocentromere Activity of Two Classes of Tandem Repeat Arrays 3

Show all 3 →
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Authors suggest microtubule-based motors mediate neocentromere motility.

Taxon
maizeZea mayse0
Outcome
motilitye1
Qualifier
microtubule-based motorse1

Verbatim

e0

“In maize, genes on abnormal chromosome 10 induce the tandem repeats that make up knobs to move poleward on the meiotic spindle”

✓ located verbatim in the source · abstract, characters 104–230
e1

“suggesting that the mechanism of motility involves microtubule-based motors”

✓ located verbatim in the source · abstract, characters 658–733

Title

Independently Regulated Neocentromere Activity of Two Classes of Tandem Repeat Arrays

Evelyn N. Hiatt; Edward K. Kentner; R. Kelly Dawe The Plant Cell 2002. doi:10.1105/tpc.010373

Other claims from this paper (5)
Mechanismobservedoriginal resultmeasured

Claim · model-written summary

At least two repeat-specific activators control neocentromere motility in trans.

Taxon
maizeZea mayse0
Gene
repeat-specific activatorse1
Outcome
motilitye1

Verbatim

e0

“In maize, genes on abnormal chromosome 10 induce the tandem repeats that make up knobs to move poleward on the meiotic spindle”

✓ located verbatim in the source · abstract, characters 104–230
e1

“their motility is controlled in trans by at least two repeat-specific activators”

✓ located verbatim in the source · abstract, characters 449–529

Title

Independently Regulated Neocentromere Activity of Two Classes of Tandem Repeat Arrays

Evelyn N. Hiatt; Edward K. Kentner; R. Kelly Dawe The Plant Cell 2002. doi:10.1105/tpc.010373

Other claims from this paper (5)
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Microtubule dynamics contributed little to neocentromere movement despite taxol.

Taxon
maizeZea mayse0
Treatment
taxole1
Outcome
movement of neocentromerese1
Qualifier
Microtubule dynamics appear to contribute littlee1

Verbatim

e0

“In maize, genes on abnormal chromosome 10 induce the tandem repeats that make up knobs to move poleward on the meiotic spindle”

✓ located verbatim in the source · abstract, characters 104–230
e1

“Microtubule dynamics appear to contribute little to the movement of neocentromeres (they are active in the presence of taxol)”

✓ located verbatim in the source · abstract, characters 531–656

Title

Independently Regulated Neocentromere Activity of Two Classes of Tandem Repeat Arrays

Evelyn N. Hiatt; Edward K. Kentner; R. Kelly Dawe The Plant Cell 2002. doi:10.1105/tpc.010373

Other claims from this paper (5)

Neocentromere-mediated Chromosome Movement in Maize 2

Show all 2 →
Mechanismauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

Microtubule depolymerization is not required for neocentromere motility.

Taxon
maizeZea mayse0
Outcome
neocentromere motilitye6
Qualifier
microtubule depolymerization is not requirede6

Verbatim

e0

“In maize, neocentromeres are induced by a gene or genes on Abnormal chromosome 10 (Ab10) which causes heterochromatic knobs to move poleward at meiotic anaphase”

✓ located verbatim in the source · abstract, characters 83–243
e6

“These data suggest that microtubule depolymerization is not required for neocentromere motility”

✓ located verbatim in the source · abstract, characters 1241–1336

Title

Neocentromere-mediated Chromosome Movement in Maize

Hong-Guo Yu; Evelyn N. Hiatt; Annette Chan; et al. The Journal of Cell Biology 1997. doi:10.1083/jcb.139.4.831

Other claims from this paper (8)
Mechanismauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

Neocentromeres are mobilized on microtubules by minus end-directed motor proteins.

Taxon
maizeZea mayse0
Outcome
mobilized on microtubulese7
Qualifier
minus end-directed motor proteinse7

Verbatim

e0

“In maize, neocentromeres are induced by a gene or genes on Abnormal chromosome 10 (Ab10) which causes heterochromatic knobs to move poleward at meiotic anaphase”

✓ located verbatim in the source · abstract, characters 83–243
e7

“We argue that neocentromeres are mobilized on microtubules by the activity of minus end-directed motor proteins”

✓ located verbatim in the source · abstract, characters 1338–1449

Title

Neocentromere-mediated Chromosome Movement in Maize

Hong-Guo Yu; Evelyn N. Hiatt; Annette Chan; et al. The Journal of Cell Biology 1997. doi:10.1083/jcb.139.4.831

Other claims from this paper (8)

PRINS-Labeled Knobs Are Not Associated with Increased Chromosomal Stickiness in the Maize st1 Mutant 2

Show all 2 →
Mechanismauthor interpretationoriginal resultnegativemeasured

Claim · model-written summary

The authors interpret increased stickiness as involving both knob and nonknob chromosome regions.

Taxon
maizeZea mayst0
Outcome
chromosomal stickinesse0
Direction
increasee0
Qualifier
stickiness of knob and nonknob chromosomal regionse0

Verbatim

e0

“Thus, the increase in chromosomal stickiness appears to be due to an increase in stickiness of knob and nonknob chromosomal regions”

✓ located verbatim in the source · abstract, characters 966–1097
t0

“PRINS-Labeled Knobs Are Not Associated with Increased Chromosomal Stickiness in the Maize st1 Mutant”

✓ located verbatim in the source · title, characters 0–100

Title

PRINS-Labeled Knobs Are Not Associated with Increased Chromosomal Stickiness in the Maize st1 Mutant

T. C. Tatum Journal of Heredity 2006. doi:10.1093/jhered/esl014

Other claims from this paper (6)
Mechanismhypothesisoriginal resultmeasured

Claim · model-written summary

The mechanism of st1 stickiness is hypothesized to differ from other reported sticky chromosome cases.

Taxon
maizeZea mayst0
Material
st1 mutante0
Outcome
mechanism responsible for the st1 mutante0
Comparator
other previously described sticky chromosomes situationse0

Verbatim

e0

“The mechanism responsible for the st1 mutant, therefore, is hypothesized to be different from that implicated in the other previously described sticky chromosomes situations”

✓ located verbatim in the source · abstract, characters 1099–1272
t0

“PRINS-Labeled Knobs Are Not Associated with Increased Chromosomal Stickiness in the Maize st1 Mutant”

✓ located verbatim in the source · title, characters 0–100

Title

PRINS-Labeled Knobs Are Not Associated with Increased Chromosomal Stickiness in the Maize st1 Mutant

T. C. Tatum Journal of Heredity 2006. doi:10.1093/jhered/esl014

Other claims from this paper (6)

CAUSES AND CONSEQUENCES OF DNA CONTENT VARIATION IN ZEA 2

Show all 2 →
Mechanismauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

The authors proposed intragenomic conflict between B chromosomes and heterochromatic knobs in maize landraces.

Taxon
maizeZea mayse1
Outcome
intragenomic conflicte0
Qualifier
Bs and heterochromatic knobse0

Verbatim

e0

“the negative relationship found between Bs and heterochromatic knobs allowed us to propose the existence of an intragenomic conflict between these elements.”

✓ located verbatim in the source · abstract, characters 1463–1619
e1

“native Argentinian and Bolivian maize landraces”

✓ located verbatim in the source · abstract, characters 232–279

Title

CAUSES AND CONSEQUENCES OF DNA CONTENT VARIATION IN ZEA

G.E. González; M.F. Realini; M.F. Fourastié; et al. Journal of Basic and Applied Genetics 2022. doi:10.35407/bag.2022.33.01.03

Other claims from this paper (10)
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Differences in knob heterochromatin and retrotransposon DNA were attributed as the main sources of genome size variation in Zea.

Taxon
ZEAZeat0
Outcome
This variatione0
Qualifier
differences in the heterochromatin located in the knobs and to the amount of interspersed DNA from retrotransposonse0

Verbatim

e0

“This variation is mainly attributed to differences in the heterochromatin located in the knobs and to the amount of interspersed DNA from retrotransposons.”

✓ located verbatim in the source · abstract, characters 610–765
t0

“ZEA”

✓ located verbatim in the source · title, characters 52–55

Title

CAUSES AND CONSEQUENCES OF DNA CONTENT VARIATION IN ZEA

G.E. González; M.F. Realini; M.F. Fourastié; et al. Journal of Basic and Applied Genetics 2022. doi:10.35407/bag.2022.33.01.03

Other claims from this paper (10)

Complex structure of knobs and centromeric regions in maize chromosomes. 2

Show all 2 →
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Maize knobs may be considered megatransposable elements.

Taxon
maizeZea mayst0
Outcome
maize knob may be consider as megatransposable elementse0
Qualifier
knob polymorphism and complex structuree0

Verbatim

e0

“knob polymorphism and complex structure suggest that maize knob may be consider as megatransposable elements”

✓ located verbatim in the source · abstract, characters 1773–1881
t0

“maize”

✓ located verbatim in the source · title, characters 54–59

Title

Complex structure of knobs and centromeric regions in maize chromosomes.

E V Ananiev; R L Phillips; H W Rines PubMed 2000

Other claims from this paper (13)
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Interspersed retrotransposable elements and tandem repeats may be a basic feature of eukaryotic heterochromatin organization.

Taxon
maizeZea mayse0
Outcome
heterochromatin organization for eukaryotese0
Qualifier
interspersion of retrotransposable elements among blocks of tandem repeatse0

Verbatim

e0

“interspersion of retrotransposable elements among blocks of tandem repeats in maize and some other organisms suggests that this pattern may be basic to heterochromatin organization for eukaryotes”

✓ located verbatim in the source · abstract, characters 1904–2099
t0

“maize”

✓ located verbatim in the source · title, characters 54–59

Title

Complex structure of knobs and centromeric regions in maize chromosomes.

E V Ananiev; R L Phillips; H W Rines PubMed 2000

Other claims from this paper (13)

Higher order repeat structures reflect diverging evolutionary paths in maize centromeres and knobs 2

Show all 2 →
Mechanismhypothesisoriginal resultmeasured

Claim · model-written summary

The repeat units in knobs likely promote unequal crossing over, enabling rapid knob expansion.

Taxon
maizeZea mayst0
Outcome
rapid knob expansione0
Qualifier
unequal crossing overe0

Verbatim

t0

“maize”

✓ located verbatim in the source · title, characters 71–76
e0

“These repeat units likely promote unequal crossing over, enabling rapid knob expansion”

✓ located verbatim in the source · abstract, characters 1395–1481

Title

Higher order repeat structures reflect diverging evolutionary paths in maize centromeres and knobs

Rebecca D. Piri; Mingyu Wang; M. Cinta Romay; et al. Genome biology 2026. doi:10.1186/s13059-026-03993-4

Other claims from this paper (9)
Mechanismhypothesisoriginal resultmeasured

Claim · model-written summary

The repeat units may harbor motifs recognized by trans-acting factors involved in meiotic drive.

Taxon
maizeZea mayst0
Outcome
meiotic drivee0
Qualifier
motifs recognized by trans-acting factorse0

Verbatim

t0

“maize”

✓ located verbatim in the source · title, characters 71–76
e0

“may harbor motifs recognized by trans-acting factors involved in meiotic drive”

✓ located verbatim in the source · abstract, characters 1487–1565

Title

Higher order repeat structures reflect diverging evolutionary paths in maize centromeres and knobs

Rebecca D. Piri; Mingyu Wang; M. Cinta Romay; et al. Genome biology 2026. doi:10.1186/s13059-026-03993-4

Other claims from this paper (9)

Genomic affinities revealed by GISH suggests intergenomic restructuring between parental genomes of the paleopolyploid genus Zea 1

Show all 1 →
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

The absence of hybridization signals in all maize knobs indicates that these heterochromatic regions were lost during Z. perennis genome evolution.

Taxon
maizeZea mayse7
Outcome
absence of hybridization signals in all maize knobse7
Qualifier
heterochromatic regions were lost during the Z. perennis genome evolutione7

Verbatim

e7

“the absence of hybridization signals in all maize knobs indicate that these heterochromatic regions were lost during the Z. perennis genome evolution”

✓ located verbatim in the source · abstract, characters 1666–1815

Title

Genomic affinities revealed by GISH suggests intergenomic restructuring between parental genomes of the paleopolyploid genus Zea

Graciela Esther González; Lidia Poggio Genome 2015. doi:10.1139/gen-2015-0081

Other claims from this paper (9)

Alanine Zipper-Like Coiled-Coil Domains Are Necessary for Homotypic Dimerization of Plant GAGA-Factors in the Nucleus and Nucleolus 1

Show all 1 →
Mechanismauthor interpretationoriginal resultsimulated

Claim · model-written summary

Predicted salt bridges and hydrogen bonds form an interaction domain differing from the classical zipper model.

Taxon
Arabidopsis thalianaArabidopsis thalianae1
Outcome
interaction domaine0
Qualifier
Interhelical salt bridges and charge-stabilized hydrogen bondse0

Verbatim

e0

“Interhelical salt bridges and charge-stabilized hydrogen bonds between acidic and basic residues of the two monomers are predicted to form an interaction domain, which does not follow the classical knobs-into-holes zipper model.”

✓ located verbatim in the source · abstract, characters 1036–1264
e1

“from Arabidopsis thaliana”

✓ located verbatim in the source · abstract, characters 432–457

Title

Alanine Zipper-Like Coiled-Coil Domains Are Necessary for Homotypic Dimerization of Plant GAGA-Factors in the Nucleus and Nucleolus

Dierk Wanke; Mareike L. Hohenstatt; Marek Dynowski; et al. PLoS ONE 2011. doi:10.1371/journal.pone.0016070

Other claims from this paper (7)

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