By interacting organism as written › L. amazonensis

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Young-leaf essential oil of Protium heptaphyllum had an IC50 of 9.02 against L. amazonensis promastigotes.

Taxon: Protium heptaphyllumProtium heptaphyllumt0
Organ / stage: fresh youngt0
Interactor: L. amazonensisLeishmania amazonensise1other
Outcome: IC50e1
Value: 9.02e1

Verbatim

t0
“Protium heptaphyllum fresh young and adult leaves”
✓ located verbatim in the source · title, characters 20–69

e1
“PY-EO and PA-EO leaves were highly active and activeagainst promastigote forms of L. amazonensis, since IC50 = 9.02 and 28.88 μg/mL, respectively”
✓ located verbatim in the source · abstract, characters 242–387

Title

Essential oils from Protium heptaphyllum fresh young and adult leaves (Burseraceae): chemical composition, in vitro leishmanicidal and cytotoxic effects

Rodrigo Sebastião Cruvinel Cabral; Cassia Cristina Fernandes; Alline Laiane Borges Dias; et al. Journal of Essential Oil Research 2021. doi:10.1080/10412905.2020.1848651

Other claims from this paper (8)

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Adult-leaf essential oil of Protium heptaphyllum had an IC50 of 28.88 against L. amazonensis promastigotes.

Taxon: Protium heptaphyllumProtium heptaphyllumt0
Organ / stage: adult leavest0
Interactor: L. amazonensisLeishmania amazonensise1other
Outcome: IC50e1
Value: 28.88e1

Verbatim

t0
“Protium heptaphyllum fresh young and adult leaves”
✓ located verbatim in the source · title, characters 20–69

e1
“PY-EO and PA-EO leaves were highly active and activeagainst promastigote forms of L. amazonensis, since IC50 = 9.02 and 28.88 μg/mL, respectively”
✓ located verbatim in the source · abstract, characters 242–387

Title

Essential oils from Protium heptaphyllum fresh young and adult leaves (Burseraceae): chemical composition, in vitro leishmanicidal and cytotoxic effects

Rodrigo Sebastião Cruvinel Cabral; Cassia Cristina Fernandes; Alline Laiane Borges Dias; et al. Journal of Essential Oil Research 2021. doi:10.1080/10412905.2020.1848651

Other claims from this paper (8)

Associationobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

Carajurin showed a significant statistical correlation with activity of A. chica extracts against L. amazonensis (p = 0.030).

Taxon: Arrabidaea chicaFridericia chicae1
Interactor: L. amazonensisLeishmania amazonensise2pathogen
Compound: carajurine2
Outcome: activity against L. amazonensise2
Value: p = 0.030e2

Not reportedDirection

Verbatim

e1
“Arrabidaea chica Verlot (crajiru)”
✓ located verbatim in the source · abstract, characters 0–33

e2
“Among anthocyanidins identified in the extracts, only carajurin showed significant statistical correlation (p = 0.030) with activity against L. amazonensis”
✓ located verbatim in the source · abstract, characters 1341–1496

Title

The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes

Carla Junqueira Moragas-Tellis; Fernando Almeida-Souza; Maria do Socorro dos Santos Chagas; et al. Molecules 2020. doi:10.3390/molecules25153547

Other claims from this paper (2)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Alpinetin inhibited L. amazonensis flagellar motility by 40.2% at 100 µM.

Taxon: Fridericia speciosaFridericia speciosat0
Treatment: compounds 1-4e5
Interactor: L. amazonensisLeishmania amazonensise5other
Compound: alpinetine2
Outcome: L. amazonensis flagellar motilitye5
Direction: inhibitede5
Value: 40.2%e5

Not reportedComparator

Verbatim

t0
“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
✓ located verbatim in the source · title, characters 0–87

e2
“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
✓ located verbatim in the source · abstract, characters 456–545

e5
“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
✓ located verbatim in the source · abstract, characters 998–1112

Title

ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES

Reinaldo Milani; Osvaine Alves; Camila Bertanha; et al. Química Nova 2020. doi:10.21577/0100-4042.20170628

Other claims from this paper (14)

Intervention effect Only the EAF fraction of Fridericia speciosa showed activity against Leishmania amazonensis, at 80.4% at 50 µg/mL.
Intervention effect LCE was active against the normal human lung fibroblast line, with IC 50 of 460.7 µg/mL.
Intervention effect EAF was active against the normal human lung fibroblast line, with IC 50 of 381.4 µg/mL.
Observation Alpinetin was quantified at 6.21% in LCE by HPLC-DAD.
Observation Alpinetin was quantified at 45.32% in EAF by HPLC-DAD.
Observation Luteolin was quantified at 1.11% in LCE by HPLC-DAD.
Observation Luteolin was quantified at 2.00% in EAF by HPLC-DAD.
Intervention effect Luteolin inhibited L. amazonensis flagellar motility by 26.8% at 100 µM.
Intervention effect Diosmetin inhibited L. amazonensis flagellar motility by 1.0% at 100 µM.
Intervention effect Apigenin inhibited L. amazonensis flagellar motility by 24.8% at 100 µM.
Intervention effect Alpinetin toxicity to the normal cell line was above 1000 µg/mL.
Intervention effect Luteolin toxicity to the normal cell was 353.0 µg/mL.
Intervention effect Diosmetin toxicity to the normal cell was 766.2 µg/mL.
Intervention effect Apigenin toxicity to the normal cell was above 1000 µg/mL.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Luteolin inhibited L. amazonensis flagellar motility by 26.8% at 100 µM.

Taxon: Fridericia speciosaFridericia speciosat0
Treatment: compounds 1-4e5
Interactor: L. amazonensisLeishmania amazonensise5other
Compound: luteoline2
Outcome: L. amazonensis flagellar motilitye5
Direction: inhibitede5
Value: 26.8%e5

Not reportedComparator

Verbatim

t0
“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
✓ located verbatim in the source · title, characters 0–87

e2
“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
✓ located verbatim in the source · abstract, characters 456–545

e5
“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
✓ located verbatim in the source · abstract, characters 998–1112

Title

ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES

Reinaldo Milani; Osvaine Alves; Camila Bertanha; et al. Química Nova 2020. doi:10.21577/0100-4042.20170628

Other claims from this paper (14)

Intervention effect Only the EAF fraction of Fridericia speciosa showed activity against Leishmania amazonensis, at 80.4% at 50 µg/mL.
Intervention effect LCE was active against the normal human lung fibroblast line, with IC 50 of 460.7 µg/mL.
Intervention effect EAF was active against the normal human lung fibroblast line, with IC 50 of 381.4 µg/mL.
Observation Alpinetin was quantified at 6.21% in LCE by HPLC-DAD.
Observation Alpinetin was quantified at 45.32% in EAF by HPLC-DAD.
Observation Luteolin was quantified at 1.11% in LCE by HPLC-DAD.
Observation Luteolin was quantified at 2.00% in EAF by HPLC-DAD.
Intervention effect Alpinetin inhibited L. amazonensis flagellar motility by 40.2% at 100 µM.
Intervention effect Diosmetin inhibited L. amazonensis flagellar motility by 1.0% at 100 µM.
Intervention effect Apigenin inhibited L. amazonensis flagellar motility by 24.8% at 100 µM.
Intervention effect Alpinetin toxicity to the normal cell line was above 1000 µg/mL.
Intervention effect Luteolin toxicity to the normal cell was 353.0 µg/mL.
Intervention effect Diosmetin toxicity to the normal cell was 766.2 µg/mL.
Intervention effect Apigenin toxicity to the normal cell was above 1000 µg/mL.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Diosmetin inhibited L. amazonensis flagellar motility by 1.0% at 100 µM.

Taxon: Fridericia speciosaFridericia speciosat0
Treatment: compounds 1-4e5
Interactor: L. amazonensisLeishmania amazonensise5other
Compound: diosmetine2
Outcome: L. amazonensis flagellar motilitye5
Direction: inhibitede5
Value: 1.0%e5

Not reportedComparator

Verbatim

t0
“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
✓ located verbatim in the source · title, characters 0–87

e2
“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
✓ located verbatim in the source · abstract, characters 456–545

e5
“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
✓ located verbatim in the source · abstract, characters 998–1112

Title

ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES

Reinaldo Milani; Osvaine Alves; Camila Bertanha; et al. Química Nova 2020. doi:10.21577/0100-4042.20170628

Other claims from this paper (14)

Intervention effect Only the EAF fraction of Fridericia speciosa showed activity against Leishmania amazonensis, at 80.4% at 50 µg/mL.
Intervention effect LCE was active against the normal human lung fibroblast line, with IC 50 of 460.7 µg/mL.
Intervention effect EAF was active against the normal human lung fibroblast line, with IC 50 of 381.4 µg/mL.
Observation Alpinetin was quantified at 6.21% in LCE by HPLC-DAD.
Observation Alpinetin was quantified at 45.32% in EAF by HPLC-DAD.
Observation Luteolin was quantified at 1.11% in LCE by HPLC-DAD.
Observation Luteolin was quantified at 2.00% in EAF by HPLC-DAD.
Intervention effect Alpinetin inhibited L. amazonensis flagellar motility by 40.2% at 100 µM.
Intervention effect Luteolin inhibited L. amazonensis flagellar motility by 26.8% at 100 µM.
Intervention effect Apigenin inhibited L. amazonensis flagellar motility by 24.8% at 100 µM.
Intervention effect Alpinetin toxicity to the normal cell line was above 1000 µg/mL.
Intervention effect Luteolin toxicity to the normal cell was 353.0 µg/mL.
Intervention effect Diosmetin toxicity to the normal cell was 766.2 µg/mL.
Intervention effect Apigenin toxicity to the normal cell was above 1000 µg/mL.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Apigenin inhibited L. amazonensis flagellar motility by 24.8% at 100 µM.

Taxon: Fridericia speciosaFridericia speciosat0
Treatment: compounds 1-4e5
Interactor: L. amazonensisLeishmania amazonensise5other
Compound: apigenine2
Outcome: L. amazonensis flagellar motilitye5
Direction: inhibitede5
Value: 24.8%e5

Not reportedComparator

Verbatim

t0
“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
✓ located verbatim in the source · title, characters 0–87

e2
“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
✓ located verbatim in the source · abstract, characters 456–545

e5
“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
✓ located verbatim in the source · abstract, characters 998–1112

Title

ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES

Reinaldo Milani; Osvaine Alves; Camila Bertanha; et al. Química Nova 2020. doi:10.21577/0100-4042.20170628

Other claims from this paper (14)

Intervention effect Only the EAF fraction of Fridericia speciosa showed activity against Leishmania amazonensis, at 80.4% at 50 µg/mL.
Intervention effect LCE was active against the normal human lung fibroblast line, with IC 50 of 460.7 µg/mL.
Intervention effect EAF was active against the normal human lung fibroblast line, with IC 50 of 381.4 µg/mL.
Observation Alpinetin was quantified at 6.21% in LCE by HPLC-DAD.
Observation Alpinetin was quantified at 45.32% in EAF by HPLC-DAD.
Observation Luteolin was quantified at 1.11% in LCE by HPLC-DAD.
Observation Luteolin was quantified at 2.00% in EAF by HPLC-DAD.
Intervention effect Alpinetin inhibited L. amazonensis flagellar motility by 40.2% at 100 µM.
Intervention effect Luteolin inhibited L. amazonensis flagellar motility by 26.8% at 100 µM.
Intervention effect Diosmetin inhibited L. amazonensis flagellar motility by 1.0% at 100 µM.
Intervention effect Alpinetin toxicity to the normal cell line was above 1000 µg/mL.
Intervention effect Luteolin toxicity to the normal cell was 353.0 µg/mL.
Intervention effect Diosmetin toxicity to the normal cell was 766.2 µg/mL.
Intervention effect Apigenin toxicity to the normal cell was above 1000 µg/mL.

Observationobservedoriginal resultmeasured

Claim · model-written summary

The leaf essential oil of Eugenia pitanga was effective against Leishmania amazonensis promastigotes with an IC50 of 6.10 ± 1.80 μg/mL.

Taxon: Eugenia pitangaEugenia pitangae0
Interactor: L. amazonensisLeishmania amazonensise3other
Outcome: IC50 valuee3
Value: 6.10 ± 1.80 μg/mLe3

Verbatim

e0
“Eugenia pitanga (O.Berg) Nied., Myrtaceae”
✓ located verbatim in the source · abstract, characters 0–41

e3
“EoEp was effective against L. amazonensis promastigotes with IC50 value of 6.10 ± 1.80 μg/mL”
✓ located verbatim in the source · abstract, characters 951–1043

Title

Chemical Composition and Evaluation Preliminary of Antileishmanial Activityin vitroof Essential Oil from Leaves ofEugenia pitanga, A Native Species of Southern of Brazil

Carla Kauffmann; Eduardo Miranda Ethur; Kelen Arossi; et al. Journal of Essential Oil Bearing Plants 2017. doi:10.1080/0972060x.2017.1281767

Other claims from this paper (5)

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

The two compounds caused ultrastructural changes in Leishmania amazonensis promastigotes, with loss of their classical structural morphology.

Taxon: C. pinnatifidaCalea pinnatifidae0
Interactor: L. amazonensisLeishmania amazonensise2other
Outcome: ultrastructural changese2
Qualifier: loss of their classical structural morphologye2

Verbatim

e0
“In present work, the bioactivity guided fractionation of crude ethanol extract from leaves of C. pinnatifida led to isolation of two sesquiterpene lactones: arucanolide and calealactone C, which structures were established on the basis of spectroscopic analysis”
✓ located verbatim in the source · abstract, characters 1212–1473

e2
“These compounds caused ultrastructural changes in L. amazonensis promastigotes leading to a loss of their classical structural morphology, as evidenced by electron microscopy”
✓ located verbatim in the source · abstract, characters 1655–1829

Title

Evaluation of in vitro activity and ultrastructural changes in Leishmania amazonensis caused by sesquiterpene lactones from Calea pinnatifida (Asteraceae)

P Sartorelli; ML Yoshinaga; MJP Ferreira; et al. Planta Medica 2016. doi:10.1055/s-0036-1596518

Other claims from this paper (5)

L. amazonensis 9 claims

9 claims