By organism › Green plants › Hypericaceae › Hypericum acmosepalum

Observationobservedoriginal resultmeasured

Claim · model-written summary

Hyperacmoses A–C and two precursor compounds were purified from Hypericum acmosepalum.

Taxon: Hypericum acmosepalumHypericum acmosepalume0
Outcome: Hyperacmoses A–Ce0
Qualifier: two processors ( 4 and 5 )e0

Verbatim

e0
“Hyperacmoses A–C, three seco-norpolyprenylated acylphloroglucinols (PPAPs) ( 1 – 3 ), along with two processors ( 4 and 5 ), were purified from Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 0–165

Title

Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity

Zhuohan Hu; Lei Huang; Lang Wang; et al. Organic Letters 2026. doi:10.1021/acs.orglett.6c00023

Other claims from this paper (9)

Observation Compounds 1 and 2 have the first reported seco-norPPAP 5/6/5/6/5 pentacyclic framework.
Observation Compound 3 has the first reported seco-norPPAP 5/5/6/6 tetracyclic core.
Observation Three rare PPAPs shared a biosynthetic precursor.
Mechanism The authors propose that oxidation at different precursor positions could yield different PPAP types.
Intervention effect Compound 1 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 2 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 4 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 5 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Mechanism Compound 1 suppressed FASN and ACACA protein expression by targeting ACSS2.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Compounds 1 and 2 have the first reported seco-norPPAP 5/6/5/6/5 pentacyclic framework.

Taxon: Hypericum acmosepalumHypericum acmosepalume1
Outcome: 5/6/5/6/5 pentacyclic frameworke0
Qualifier: first seco-norPPAPe0

Verbatim

e0
“compounds 1 and 2 represent the first seco-norPPAP with an unprecedented 5/6/5/6/5 pentacyclic framework”
✓ located verbatim in the source · abstract, characters 182–286

e1
“Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 144–165

Title

Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity

Zhuohan Hu; Lei Huang; Lang Wang; et al. Organic Letters 2026. doi:10.1021/acs.orglett.6c00023

Other claims from this paper (9)

Observation Hyperacmoses A–C and two precursor compounds were purified from Hypericum acmosepalum.
Observation Compound 3 has the first reported seco-norPPAP 5/5/6/6 tetracyclic core.
Observation Three rare PPAPs shared a biosynthetic precursor.
Mechanism The authors propose that oxidation at different precursor positions could yield different PPAP types.
Intervention effect Compound 1 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 2 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 4 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 5 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Mechanism Compound 1 suppressed FASN and ACACA protein expression by targeting ACSS2.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Compound 3 has the first reported seco-norPPAP 5/5/6/6 tetracyclic core.

Taxon: Hypericum acmosepalumHypericum acmosepalume1
Outcome: 5/5/6/6 tetracyclic coree0
Qualifier: first seco-norPPAPe0

Verbatim

e0
“compound 3 is the first seco-norPPAP with a 5/5/6/6 tetracyclic core”
✓ located verbatim in the source · abstract, characters 294–362

e1
“Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 144–165

Title

Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity

Zhuohan Hu; Lei Huang; Lang Wang; et al. Organic Letters 2026. doi:10.1021/acs.orglett.6c00023

Other claims from this paper (9)

Observation Hyperacmoses A–C and two precursor compounds were purified from Hypericum acmosepalum.
Observation Compounds 1 and 2 have the first reported seco-norPPAP 5/6/5/6/5 pentacyclic framework.
Observation Three rare PPAPs shared a biosynthetic precursor.
Mechanism The authors propose that oxidation at different precursor positions could yield different PPAP types.
Intervention effect Compound 1 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 2 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 4 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 5 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Mechanism Compound 1 suppressed FASN and ACACA protein expression by targeting ACSS2.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Three rare PPAPs shared a biosynthetic precursor.

Taxon: Hypericum acmosepalumHypericum acmosepalume1
Outcome: same biosynthetic precursore0

Verbatim

e0
“Three rare PPAPs had the same biosynthetic precursor”
✓ located verbatim in the source · abstract, characters 364–416

e1
“Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 144–165

Title

Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity

Zhuohan Hu; Lei Huang; Lang Wang; et al. Organic Letters 2026. doi:10.1021/acs.orglett.6c00023

Other claims from this paper (9)

Observation Hyperacmoses A–C and two precursor compounds were purified from Hypericum acmosepalum.
Observation Compounds 1 and 2 have the first reported seco-norPPAP 5/6/5/6/5 pentacyclic framework.
Observation Compound 3 has the first reported seco-norPPAP 5/5/6/6 tetracyclic core.
Mechanism The authors propose that oxidation at different precursor positions could yield different PPAP types.
Intervention effect Compound 1 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 2 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 4 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 5 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Mechanism Compound 1 suppressed FASN and ACACA protein expression by targeting ACSS2.

Mechanismhypothesisoriginal resultmeasured

Claim · model-written summary

The authors propose that oxidation at different precursor positions could yield different PPAP types.

Taxon: Hypericum acmosepalumHypericum acmosepalume1
Outcome: different types of PPAPs ( 1 – 3 )e0
Qualifier: Baeyer–Villiger oxidation of this precursor at different positionse0

Verbatim

e0
“Baeyer–Villiger oxidation of this precursor at different positions could finally give different types of PPAPs ( 1 – 3 )”
✓ located verbatim in the source · abstract, characters 422–542

e1
“Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 144–165

Title

Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity

Zhuohan Hu; Lei Huang; Lang Wang; et al. Organic Letters 2026. doi:10.1021/acs.orglett.6c00023

Other claims from this paper (9)

Observation Hyperacmoses A–C and two precursor compounds were purified from Hypericum acmosepalum.
Observation Compounds 1 and 2 have the first reported seco-norPPAP 5/6/5/6/5 pentacyclic framework.
Observation Compound 3 has the first reported seco-norPPAP 5/5/6/6 tetracyclic core.
Observation Three rare PPAPs shared a biosynthetic precursor.
Intervention effect Compound 1 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 2 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 4 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Intervention effect Compound 5 inhibited triglycerides in oleic acid-induced HepG2 cells better than atorvastatin.
Mechanism Compound 1 suppressed FASN and ACACA protein expression by targeting ACSS2.

Observationobservedoriginal resultmeasured

Claim · model-written summary

The chloroplast genome of Hypericum acmosepalum was 152,654 bp in size.

Taxon: Hypericum acmosepalumHypericum acmosepalume0
Outcome: chloroplast genome sizese1
Value: 152,654 bpe1

Verbatim

e0
“Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 232–253

e1
“The chloroplast genome sizes were 152,654 bp, 122,570 bp, and 137,652 bp, respectively”
✓ located verbatim in the source · abstract, characters 365–451

Title

Chloroplast Genome Diversity and Molecular Evolution in Hypericaceae: New Insights from Three Hypericum Species

Kan Yan; Xin Lu; Wandi Li; et al. International Journal of Molecular Sciences 2025. doi:10.3390/ijms26010323

Other claims from this paper (13)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Phylogenetic analysis placed H. acmosepalum and H. beanii as closest relatives, with Hypericum hookerianum as their sister species.

Taxon: H. acmosepalum and H. beaniiHypericum acmosepalumHypericum beaniie1
Outcome: closest relativese1

Verbatim

e1
“H. acmosepalum and H. beanii being closest relatives and Hypericum hookerianum as their sister species”
✓ located verbatim in the source · abstract, characters 1167–1269

Title

Chloroplast Genome Diversity and Molecular Evolution in Hypericaceae: New Insights from Three Hypericum Species

Kan Yan; Xin Lu; Wandi Li; et al. International Journal of Molecular Sciences 2025. doi:10.3390/ijms26010323

Other claims from this paper (13)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Two previously undescribed polycyclic polyprenylated acylphloroglucinols were obtained from the aerial parts of Hypericum acmosepalum.

Taxon: Hypericum acmosepalumHypericum acmosepalumt0
Organ / stage: aerial partse1
Outcome: previously undescribed polycyclic polyprenylated acylphloroglucinolse1

Verbatim

t0
“from Hypericum acmosepalum”
✓ located verbatim in the source · title, characters 86–112

e1
“Two previously undescribed polycyclic polyprenylated acylphloroglucinols, hyperacmosins R-S (1–2), were obtained from the aerial parts of Hypericum acmosepalum”
✓ located verbatim in the source · abstract, characters 0–159

Title

Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Hypericum acmosepalum

Yonghui Ma; Xiaoyu Liu; Bo Liu; et al. Molecules 2022. doi:10.3390/molecules27185932

Other claims from this paper (4)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Compound 1 has an unprecedented 5,8-spiroketal subunit.

Taxon: Hypericum acmosepalumHypericum acmosepalumt0
Outcome: unprecedented 5,8-spiroketal subunite2

Verbatim

t0
“from Hypericum acmosepalum”
✓ located verbatim in the source · title, characters 86–112

e2
“Compound 1 featured an unprecedented 5,8-spiroketal subunit as well as the loss of C-2′ carbonyl in the phloroglucinol ring”
✓ located verbatim in the source · abstract, characters 283–406

Title

Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Hypericum acmosepalum

Yonghui Ma; Xiaoyu Liu; Bo Liu; et al. Molecules 2022. doi:10.3390/molecules27185932

Other claims from this paper (4)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Compound 1 lacks the C-2′ carbonyl in its phloroglucinol ring.

Taxon: Hypericum acmosepalumHypericum acmosepalumt0
Outcome: loss of C-2′ carbonyl in the phloroglucinol ringe2

Verbatim

t0
“from Hypericum acmosepalum”
✓ located verbatim in the source · title, characters 86–112

e2
“Compound 1 featured an unprecedented 5,8-spiroketal subunit as well as the loss of C-2′ carbonyl in the phloroglucinol ring”
✓ located verbatim in the source · abstract, characters 283–406

Title

Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Hypericum acmosepalum

Yonghui Ma; Xiaoyu Liu; Bo Liu; et al. Molecules 2022. doi:10.3390/molecules27185932

Other claims from this paper (4)

Hypericum acmosepalum 35 claims

35 claims