Intervention effectmodel-written summary

Silencing clade B eEF1A reduced PPV accumulation in Nicotiana benthamiana.

A claim from Targeting ParPMC Susceptibility Hubs in Prunus : eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana · 2026

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Silencing clade B eEF1A reduced PPV accumulation in Nicotiana benthamiana.

Taxon
Nicotiana benthamianaNicotiana benthamianae0
Treatment
silencing clade B eEF1A isoformse0
Interactor
PPVe0pathogen
Gene
clade B eEF1A isoformse0
Outcome
PPV accumulatione0
Direction
reducede0

Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Nicotiana benthamiana
Nicotiana benthamiana · TaxonCharles Andres · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“silencing clade B eEF1A isoforms in Nicotiana benthamiana using a cucumber mosaic virus-based virus-induced gene silencing system strongly reduced PPV accumulation and systemic spread”

✓ located verbatim in the source · abstract, characters 1213–1396

Title

Targeting ParPMC Susceptibility Hubs in Prunus : eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana

Ángela Polo‐Oltra; Alba Lloret; Jesús A. Sánchez‐Navarro; et al. Molecular Plant Pathology 2026. doi:10.1111/mpp.70247

Other claims from this paper (7)

Record rev-33afeaaaa02f73e0c8bf62e7a9a51d04adc0b72aa892a6cbce36e439180e2beb · schema claims-v0.9 · position 5 in the model’s answer

loss of function · molecular: metabolites · Nicotiana benthamianaPositive and negative results

35 papers: 10 positive, 25 negative or no effect

9 papers in the same direction as this claim · 25 in the opposite direction

  1. negative
    NbNR silencing compromised systemic NO accumulation.

    Orchestration of hydrogen peroxide and nitric oxide in brassinosteroid‐mediated systemic virus resistance in Nicotiana benthamiana · 2016

    Opposite direction

  2. negative
    DNA ligase 1 silencing decreased PSTVd accumulation in Nicotiana benthamiana.

    Viroid RNA redirects host DNA ligase 1 to act as an RNA ligase · 2012

    Opposite direction

  3. no effect
    E2F element mutation did not affect PCNA promoter activity in young leaves.

    Proliferating Cell Nuclear Antigen Transcription Is Repressed through an E2F Consensus Element and Activated by Geminivirus Infection in Mature Leaves · 2001 · compared with healthy mature leaves

    Opposite direction

  4. negative
    Downregulation of psaK in N. benthamiana increased PPV accumulation.

    Identification of a Plum pox virus CI-Interacting Protein from Chloroplast That Has a Negative Effect in Virus Infection · 2006

    Opposite direction

  5. negative
    Silencing Nb-ABCG1/2 compromised capsidiol secretion.

    The Full-Size ABCG Transporters Nb-ABCG1 and Nb-ABCG2 Function in Pre- and Postinvasion Defense against Phytophthora infestans in Nicotiana benthamiana · 2016

    Opposite direction

  6. negative
    Silencing NbRBOHB compromised the BR-induced alternative respiratory pathway.

    The alternative respiratory pathway is involved in brassinosteroid-induced environmental stress tolerance inNicotiana benthamiana · 2015

    Opposite direction

  7. negative
    HIR3 silencing increased RSV RNA accumulation in N. benthamiana.

    The hypersensitive induced reaction 3 (HIR3) gene contributes to plant basal resistance via an EDS1 and salicylic acid‐dependent pathway · 2019

    Opposite direction

  8. negative
    Silencing AKR1 homologues in Nicotiana benthamiana increased sensitivity to glyphosate.

    Aldo‐keto reductase enzymes detoxify glyphosate and improve herbicide resistance in plants · 2016

    Opposite direction

26 papers more in this group

See all 35 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.