Intervention effectmodel-written summary

C2 expression induced necrotic vein banding and severe necrosis on systemic leaves.

A claim from Gene C2 of the Monopartite Geminivirus Tomato yellow leaf curl virus-China Encodes a Pathogenicity Determinant That Is Localized in the Nucleus · 2001

Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

C2 expression induced necrotic vein banding and severe necrosis on systemic leaves.

Taxon
Nicotiana benthamianaNicotiana benthamianae0
Treatment
Expression of the Tomato yellow leaf curl virus-China (TYLCV-C) C2 proteine0
Interactor
Tomato yellow leaf curl virus-Chinae0pathogen
Outcome
necrotic vein banding and severe necrosis on systemically infected leavese0

Not reportedMaterialGeneCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingDirectionValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Nicotiana benthamiana
Nicotiana benthamiana · TaxonCharles Andres · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“Expression of the Tomato yellow leaf curl virus-China (TYLCV-C) C2 protein and green fluorescent protein (GFP) fused to the C2 protein (C2-GFP) in Nicotiana benthamiana from a Potato virus X (PVX) vector induced necrotic ringspots on inoculated leaves as well as necrotic vein banding and severe necrosis on systemically infected leaves”

✓ located verbatim in the source · abstract, characters 0–336

Title

Gene C2 of the Monopartite Geminivirus Tomato yellow leaf curl virus-China Encodes a Pathogenicity Determinant That Is Localized in the Nucleus

Rene van Wezel; Huangting Liu; Po Tien; et al. Molecular Plant-Microbe Interactions 2001. doi:10.1094/mpmi.2001.14.9.1125

Other claims from this paper (2)

Record rev-55e359578adbc7339efed6666dd6925f80b7a8eaeb15415856f9561745c60a05 · schema claims-v0.9 · position 2 in the model’s answer

China · disease · Nicotiana benthamianaResults agree

2 papers: 0 positive, 2 negative or no effect

1 paper in the same direction as this claim

  1. negative
    sgRNAs targeting TYLCCNV/TYLCCNB did not confer resistance to other geminiviruses.

    Knockout of the virus replication‐related genes UbEF1B and CCR4/NOT3 by CRISPR/Cas9 confers high‐efficiency and broad‐spectrum resistance to geminiviruses in Nicotiana benthamiana · 2023

    Same direction

See all 2 papers →

Solanum lycopersicum · disease · Nicotiana benthamianaResults agree

6 papers: 0 positive, 6 negative or no effect

5 papers in the same direction as this claim

  1. negative
    Reduced Sl-Ubc13-2 expression diminished Fen-mediated and other R-protein-associated cell death in Nicotiana leaves.

    The Tomato Fni3 Lysine-63–Specific Ubiquitin-Conjugating Enzyme and Suv Ubiquitin E2 Variant Positively Regulate Plant Immunity · 2013

    Same direction

  2. negative
    PepLCLV with the DNA B component of ToLCNDV induced leaf curl symptoms in Nicotiana benthamiana.

    Pepper leaf curl Lahore virus requires the DNA B component of Tomato leaf curl New Delhi virus to cause leaf curl symptoms · 2010

    Same direction

  3. negative
    Co-inoculation with ChLCB intensified ToLCNDV disease symptoms.

    Chili leaf curl betasatellite enhances symptoms induced by Tomato leaf curl New Delhi virus, a bipartite begomovirus. · 2014

    Same direction

  4. negative
    sgRNAs targeting TYLCCNV/TYLCCNB did not confer resistance to other geminiviruses.

    Knockout of the virus replication‐related genes UbEF1B and CCR4/NOT3 by CRISPR/Cas9 confers high‐efficiency and broad‐spectrum resistance to geminiviruses in Nicotiana benthamiana · 2023

    Same direction

  5. negative
    The non-cognate interaction between ToLCJoV and ToLCBDB caused more severe symptoms than the cognate combination.

    Transreplication Preference of the Tomato Leaf Curl Joydebpur Virus for a Noncognate Betasatellite through Iteron Resemblance on Nicotiana bethamiana · 2023 · compared with cognate combination (ToLCJoV × ToLCJoB)

    Same direction

See all 6 papers →

transgenic · disease · Nicotiana benthamianaPositive and negative results

53 papers: 26 positive, 27 negative or no effect

26 papers in the same direction as this claim · 26 in the opposite direction

  1. positive
    PaLCuV C2 expression inhibited V2-induced hypersensitive response in the infiltrated area.

    The hypersensitive response induced by the V2 protein of a monopartite begomovirus is countered by the C2 protein · 2009

    Opposite directionCites this paper

  2. negative
    Antisense SNF1 expression enhances susceptibility in Nicotiana benthamiana.

    Geminivirus AL2 and L2 Proteins Interact with and Inactivate SNF1 Kinase · 2003 · compared with AL2 and L2 transgenes

    Same directionCites this paper

  3. negative
    Transient ACMV Rep expression triggered an HR-like response.

    Differential roles of geminivirus Rep and AC4 (C4) in the induction of necrosis in Nicotiana benthamiana · 2002

    Same directionCites this paper

  4. positive
    Direct MP repeats increased the resistant-line frequency from 20 to 60% relative to a single MP transgene.

    RNA-Mediated Virus Resistance: Role of Repeated Transgenes and Delineation of Targeted Regions. · 1996 · compared with a single MP transgene

    Opposite direction

  5. positive
    Serial infection of transformants further decreased symptom severity.

    Defective viral DNA ameliorates symptoms of geminivirus infection in transgenic plants. · 1990

    Opposite direction

  6. positive
    Truncated RPS4 expression induced cell death in Nicotiana benthamiana without AvrRps4.

    Alternative Splicing and mRNA Levels of the Disease Resistance Gene RPS4 Are Induced during Defense Responses · 2007

    Opposite direction

  7. positive
    Transformation of N. benthamiana with Pto confers specific resistance to P. s. pv tabaci strains carrying avrPto.

    Intergeneric transfer and functional expression of the tomato disease resistance gene Pto. · 1995

    Opposite direction

  8. positive
    Transient allele expression enhanced heat tolerance in Nicotiana benthamiana.

    Engineering heat tolerance in potato by temperature‐dependent expression of a specific allele of HEAT‐SHOCK COGNATE 70 · 2017

    Opposite direction

44 papers more in this group

See all 53 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.