Claim · model-written summary
Sucrose rescues the arrested sdp6 seedling growth phenotype.
- Taxon
- Arabidopsis
Arabidopsist0 - Material
- sdp6e0
- Treatment
- sucrosee0
- Outcome
- arrested seedling growth phenotypee0
- Direction
- rescuee0
Not reportedGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the arrested seedling growth phenotype of sdp6 and explain its rescue by sucrose and glucose but not by fructose”
t0“Arabidopsis”
Title
Anne-Laure Quettier; Eve Shaw; Peter J. Eastmond PLANT PHYSIOLOGY 2008. doi:10.1104/pp.108.123703
Other claims from this paper (16)
- Observation sdp6 mutants could break down triacylglycerol after germination.
- Observation sdp6 mutants failed to accumulate soluble sugars after germination.
- Mechanism sdp6 mutant results suggest a gluconeogenesis defect.
- Observation SDP6 encodes mitochondrial FAD-GPDH.
- Observation Germinated sdp6 seeds were severely impaired in glycerol metabolism to carbon dioxide.
- Observation Germinated sdp6 seeds accumulated high G3P levels.
- Mechanism The data suggest SDP6 is essential for glycerol catabolism.
- Intervention effect G3P competitively inhibited phosphoglucose isomerase activity in vitro.
- Observation Feeding labeled glucose to sdp6 seedlings showed a sixfold reduction in label transfer to the opposing sucrose hexosyl moiety.
- Observation Feeding labeled fructose to sdp6 seedlings showed a sixfold reduction in label transfer to the opposing sucrose hexosyl moiety.
- Mechanism Phosphoglucose isomerase is likely inhibited in vivo in sdp6 seedlings.
- Mechanism A gluconeogenesis block at hexose phosphate isomerization could explain arrested sdp6 seedling growth.
- Intervention effect Glucose rescues the arrested sdp6 seedling growth phenotype.
- Intervention effect Fructose does not rescue the arrested sdp6 seedling growth phenotype.
- Observation NAD(+) and NADH measurements suggest altered NAD(+)/NADH homeostasis in sdp6 seedlings.
- Mechanism The homeostasis result supports the hypothesis that SDP6 cooperates with GPDHC1 in a mitochondrial G3P shuttle.