Claim · model-written summary
Wild Solanum chacoense PI458310 resists Colorado potato beetle through leptine accumulation.
- Taxon
- Solanum chacoense PI458310
Solanum chacoensee0 - Material
- PI458310e0
- Compound
- leptine I/IIe0
- Outcome
- resistancee0
Verbatim
e0“the wild species Solanum chacoense PI458310 displays resistance through the accumulation of the specific SGAs leptine I/II”
Title
Ryota Akiyama; Yuki Ikeyama; Hyoung Jae Lee; et al. Proceedings of the National Academy of Sciences 2026. doi:10.1073/pnas.2537847123
Other claims from this paper (8)
- Mechanism Leptinines and leptines arise from transformed spirosolane-type precursors rather than direct modification of α-chaconine/α-solanine.
- Observation Sc23DOX was identified as a spirosolane C-23 hydroxylase.
- Observation Sc23ACT was identified as a 23-O-acetyltransferase.
- Mechanism Sc23DOX and Sc23ACT convert α/β-solamarine into hydroxylated and acetylated intermediates in vitro.
- Mechanism DPS, RPG1 and RPG2 process intermediates into leptinines and leptines.
- Intervention effect Heterologous Sc23DOX and Sc23ACT expression produced leptinines and leptines de novo in cultivated potato.
- Observation Many cultivated potatoes retain apparently functional 23DOX and 23ACT orthologues.
- Intervention effect Expression of 23DOX alone restores leptine biosynthesis in some cultivars.
Potato virus Y