Abstract
Extensive searches have so far failed to identify functional plant homologues of the mammalian apoptotic machinery. Here we report the isolation and characterisation of an Arabidopsis thaliana homologue of human Bax Inhibitor-1, AtBI-1, isolated during a differential screen of plants challenged with the phytopathogen Pseudomonas syringae. AtBI is a member of a small gene family in Arabidopsis, members of which display extensive amino acid identity to human BI-1. AtBI-1 is also functionally similar to BI-1 in its ability to suppress the lethal phenotype in yeast conferred by expression of the mammalian proapoptotic protein, Bax. Expression of AtBI-1 is rapidly upregulated in plants during wounding or pathogen challenge, suggesting a role in responses to biotic and abiotic stress. AtBI-1 upregulation appears R gene independent and is not markedly affected by mutations required for specific classes of R genes. However, the accumulation of AtBI-1 message is significantly reduced in coi1, in which defence responses to insects, pathogens and wounding are compromised.
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Claims 5
Claim · model-written summary
AtBI-1 suppressed Bax-induced lethal phenotype in yeast.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae0 - Treatment
- expression of the mammalian proapoptotic protein, Baxe1
- Gene
- AtBI-1e1
- Outcome
- lethal phenotypee1
- Direction
- decreaseinferrede1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“an Arabidopsis thaliana homologue of human Bax Inhibitor-1, AtBI-1, isolated during a differential screen of plants challenged with the phytopathogen Pseudomonas syringae”
e1“AtBI-1 is also functionally similar to BI-1 in its ability to suppress the lethal phenotype in yeast conferred by expression of the mammalian proapoptotic protein, Bax”
Claim · model-written summary
AtBI-1 expression was rapidly upregulated during wounding or pathogen challenge.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0
- Treatment
- wounding or pathogen challengee2
- Interactor
- Pseudomonas syringae
Pseudomonas syringaee0pathogen - Gene
- AtBI-1e2
- Outcome
- Expression of AtBI-1e2
- Direction
- upregulatede2
- Qualifier
- rapidlye2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“an Arabidopsis thaliana homologue of human Bax Inhibitor-1, AtBI-1, isolated during a differential screen of plants challenged with the phytopathogen Pseudomonas syringae”
e2“Expression of AtBI-1 is rapidly upregulated in plants during wounding or pathogen challenge”
Claim · model-written summary
AtBI-1 upregulation was not markedly affected by mutations in R gene classes, indicating R gene independence.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0
- Treatment
- mutations required for specific classes of R genese3
- Gene
- AtBI-1e3
- Outcome
- AtBI-1 upregulatione3
- Direction
- no_changeinferrede3
- Qualifier
- R gene independente3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“an Arabidopsis thaliana homologue of human Bax Inhibitor-1, AtBI-1, isolated during a differential screen of plants challenged with the phytopathogen Pseudomonas syringae”
e3“AtBI-1 upregulation appears R gene independent and is not markedly affected by mutations required for specific classes of R genes”
Claim · model-written summary
AtBI-1 message accumulation was significantly reduced in coi1 mutants.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0
- Treatment
- coi1e4
- Gene
- AtBI-1e4
- Outcome
- accumulation of AtBI-1 messagee4
- Direction
- reducede4
- Qualifier
- defence responses to insects, pathogens and wounding are compromisede4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“an Arabidopsis thaliana homologue of human Bax Inhibitor-1, AtBI-1, isolated during a differential screen of plants challenged with the phytopathogen Pseudomonas syringae”
e4“However, the accumulation of AtBI-1 message is significantly reduced in coi1, in which defence responses to insects, pathogens and wounding are compromised”
Claim · model-written summary
AtBI is a member of a small gene family in Arabidopsis with extensive amino acid identity to human BI-1.
- Taxon
- ArabidopsisArabidopsise5
- Gene
- AtBIe5
- Outcome
- amino acid identity to human BI-1e5
- Qualifier
- extensivee5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e5“AtBI is a member of a small gene family in Arabidopsis, members of which display extensive amino acid identity to human BI-1”
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