Abstract
The aim of the present study was to evaluate mitotic abnormality and micronuclei inducing potentials of colchicine and the leaf aqueous extracts of Clerodendrum viscosum (LAECV) in Allium cepa root apical meristem cells. A. cepa roots were exposed to LAECV (1–8 mg ml–1) and colchicine (0.4 mg ml–1) for 4 h and allowed to recover in water for 16 h. Root tips (treated and recovery samples) were fixed, stained and squashed; the mitotic abnormalities and micronuclei frequency were analyzed under light microscope. The microscopic study revealed both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei, along with a reduction in mitotic index in onion root apical meristem cells. Thus cyto-genotoxic effects of colchicine and LAECV are explored and compared here. Data indicate colchicine and LAECV treatment show similarity in cyto-genotoxic potentials. In conclusion, as both the substances have therapeutic potentials and also with cyto-genotoxic actions; therefore, extreme caution should be exercised in prescribing them in medication.
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Claims 7
Claim · model-written summary
Colchicine induced several mitotic abnormalities in onion root apical meristem cells.
- Taxon
- Allium cepa
Allium cepat0 - Organ / stage
- root apical meristem cellst0
- Treatment
- colchicinee0
- Outcome
- mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridgese0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges”
e1“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges”
t0“Allium ceparoot apical meristem cells”
t1“Allium ceparoot apical meristem cells”
Claim · model-written summary
LAECV induced several mitotic abnormalities in onion root apical meristem cells.
- Taxon
- Allium cepaAllium cepat0
- Organ / stage
- root apical meristem cellst0
- Treatment
- LAECVe0
- Outcome
- mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridgese0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges”
e1“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges”
t0“Allium ceparoot apical meristem cells”
t1“Allium ceparoot apical meristem cells”
Claim · model-written summary
Colchicine increased micronuclei frequency in onion root cells.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- colchicinee0
- Outcome
- frequency of micronucleie0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei”
e1“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei”
t0“Allium ceparoot apical meristem cells”
t1“Allium ceparoot apical meristem cells”
Claim · model-written summary
LAECV increased micronuclei frequency in onion root cells.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- LAECVe0
- Outcome
- frequency of micronucleie0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei”
e1“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei”
t0“colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells”
t1“colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells”
Claim · model-written summary
Colchicine reduced mitotic index in onion root cells.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- colchicinet0
- Outcome
- mitotic indexe0
- Direction
- reductione0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“a reduction in mitotic index in onion root apical meristem cells”
e1“a reduction in mitotic index in onion root apical meristem cells”
t0“colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells”
t1“colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells”
Claim · model-written summary
LAECV reduced mitotic index in onion root cells.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- LAECVe0
- Outcome
- mitotic indexe0
- Direction
- reductione0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei, along with a reduction in mitotic index in onion root apical meristem cells”
e1“both colchicine and LAECV treatment could induce different types of mitotic abnormalities including c-metaphase, vagrant chromosomes, sticky chromosomes, anaphase bridges and increased frequency of micronuclei, along with a reduction in mitotic index in onion root apical meristem cells”
t0“colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells”
t1“colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells”
Claim · model-written summary
Colchicine and LAECV showed similar cytogenotoxic potential.
- Taxon
- Allium cepaAllium cepat0
- Outcome
- similarity in cyto-genotoxic potentialse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Data indicate colchicine and LAECV treatment show similarity in cyto-genotoxic potentials.”
e1“Data indicate colchicine and LAECV treatment show similarity in cyto-genotoxic potentials.”
t0“Allium ceparoot apical meristem cells”
t1“Allium ceparoot apical meristem cells”
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