Claim · model-written summary
CRISPR/Cas9 inactivation of VIR1 enhanced viral small interfering RNA production.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Treatment
- genetic inactivation by CRISPR/Cas9 editinge0
- Gene
- Antiviral RNAi Regulator 1 (VIR1)e0
- Outcome
- vsiRNA productione0
- Direction
- enhancese0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Interestingly, the second gene, designated Antiviral RNAi Regulator 1 (VIR1), dampens antiviral RNAi so its genetic inactivation by CRISPR/Cas9 editing enhances both vsiRNA production and CMV resistance.”
t0“Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana”
Title
Si Liu; Meijuan Chen; Ruidong Li; et al. Nature Communications 2022. doi:10.1038/s41467-022-30771-0
Other claims from this paper (4)
- Association The top gene from both association screens regulated antiviral RNA interference.
- Mechanism RDO5 promoted viral small interfering RNA amplification and enhanced resistance.
- Mechanism VIR1 dampened antiviral RNA interference.
- Intervention effect CRISPR/Cas9 inactivation of VIR1 enhanced CMV resistance.