By organism › Green plants › Ranunculaceae › Hydrastis canadensis

Method / resourceobservedoriginal resultpositivemeasured

Claim · model-written summary

The alkaloid isolation experiment was fully validated in the class setting with about 160 third-year pharmacy students.

Taxon: Hydrastis canadensisHydrastis canadensise0
Outcome: validated in the class settinge3
Value: circa 160e3
Setting: class settinge3

Verbatim

e0
“Goldenseal ( Hydrastis canadensis L., Ranunculaceae) is a traditional North American herbal medicine”
✓ located verbatim in the source · abstract, characters 51–151

e3
“The experiment has been fully validated in the class setting, having been completed by circa 160 third year pharmacy students”
✓ located verbatim in the source · abstract, characters 1705–1830

Title

Studies on the Isolation and Structure Elucidation of Berberine, (−)-β-Hydrastine, and Jatrorrhizine from Goldenseal Root (Hydrastis canadensis L.) and Mahonia x media ‘Winter Sun’ Stem Bark

Minchao Guo; Muhammad Waleed Baig; Shane Carney; et al. Journal of Chemical Education 2025. doi:10.1021/acs.jchemed.4c01132

Other claims from this paper (2)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Goldenseal root ethanolic extracts gave the most potent inhibition of fungal growth, stronger than goldenseal root aqueous and leaf ethanolic extracts.

Taxon: GoldensealHydrastis canadensise0
Treatment: goldenseal root ethanolic extractse0
Outcome: fungal growthe0
Direction: most potent inhibitione0
Comparator: goldenseal root aqueous extracts and leaf ethanolic extractse0

Verbatim

t0
“Goldenseal (Hydrastis canadensis L.)”
✓ located verbatim in the source · title, characters 0–36

e0
“Goldenseal root ethanolic extracts exhibited the most potent inhibition against fungal growth, while goldenseal root aqueous extracts and leaf ethanolic extracts showed only moderate inhibition”
✓ located verbatim in the source · abstract, characters 824–1017

Title

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao; Ethan Swiggart; Kaela Wolkiewicz; et al. Molecules 2024. doi:10.3390/molecules29030556

Other claims from this paper (6)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

At 2% (m/v), goldenseal root ethanolic extract gave an inhibition rate of 86.0% against A. panax.

Taxon: GoldensealHydrastis canadensist0
Treatment: goldenseal root ethanolic extractse1
Interactor: A. panaxAlternaria panaxe1pathogen
Outcome: inhibition ratee1
Direction: increaseinferrede1
Value: 86.0%e1
Qualifier: 2% (m/v) concentratione1

Not reportedComparator

Verbatim

t0
“Goldenseal (Hydrastis canadensis L.)”
✓ located verbatim in the source · title, characters 0–36

e1
“At 2% (m/v) concentration, goldenseal root ethanolic extracts showed an inhibition rate of 86.0%, 94.9%, and 39.1% against A. panax, F. sporotrichioides, and P. nanjingensis, respectively”
✓ located verbatim in the source · abstract, characters 1019–1206

Title

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao; Ethan Swiggart; Kaela Wolkiewicz; et al. Molecules 2024. doi:10.3390/molecules29030556

Other claims from this paper (6)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

At 2% (m/v), goldenseal root ethanolic extract gave an inhibition rate of 94.9% against F. sporotrichioides.

Taxon: GoldensealHydrastis canadensist0
Treatment: goldenseal root ethanolic extractse1
Interactor: F. sporotrichioidesFusarium sporotrichioidese1pathogen
Outcome: inhibition ratee1
Direction: increaseinferrede1
Value: 94.9%e1
Qualifier: 2% (m/v) concentratione1

Not reportedComparator

Verbatim

t0
“Goldenseal (Hydrastis canadensis L.)”
✓ located verbatim in the source · title, characters 0–36

e1
“At 2% (m/v) concentration, goldenseal root ethanolic extracts showed an inhibition rate of 86.0%, 94.9%, and 39.1% against A. panax, F. sporotrichioides, and P. nanjingensis, respectively”
✓ located verbatim in the source · abstract, characters 1019–1206

Title

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao; Ethan Swiggart; Kaela Wolkiewicz; et al. Molecules 2024. doi:10.3390/molecules29030556

Other claims from this paper (6)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

At 2% (m/v), goldenseal root ethanolic extract gave an inhibition rate of 39.1% against P. nanjingensis.

Taxon: GoldensealHydrastis canadensist0
Treatment: goldenseal root ethanolic extractse1
Interactor: P. nanjingensisPestalotiopsis nanjingensise1pathogen
Outcome: inhibition ratee1
Direction: increaseinferrede1
Value: 39.1%e1
Qualifier: 2% (m/v) concentratione1

Not reportedComparator

Verbatim

t0
“Goldenseal (Hydrastis canadensis L.)”
✓ located verbatim in the source · title, characters 0–36

e1
“At 2% (m/v) concentration, goldenseal root ethanolic extracts showed an inhibition rate of 86.0%, 94.9%, and 39.1% against A. panax, F. sporotrichioides, and P. nanjingensis, respectively”
✓ located verbatim in the source · abstract, characters 1019–1206

Title

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao; Ethan Swiggart; Kaela Wolkiewicz; et al. Molecules 2024. doi:10.3390/molecules29030556

Other claims from this paper (6)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Goldenseal root ethanolic extract caused considerable morphological alterations in the mycelia of the pathogens.

Taxon: GoldensealHydrastis canadensist0
Treatment: goldenseal root ethanolic extracte3
Outcome: myceliae3
Qualifier: considerable morphological alterationse3

Not reportedComparatorDirection

Verbatim

t0
“Goldenseal (Hydrastis canadensis L.)”
✓ located verbatim in the source · title, characters 0–36

e3
“The mycelia of the pathogens treated with the goldenseal root ethanolic extract displayed considerable morphological alterations”
✓ located verbatim in the source · abstract, characters 1355–1483

Title

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao; Ethan Swiggart; Kaela Wolkiewicz; et al. Molecules 2024. doi:10.3390/molecules29030556

Other claims from this paper (6)

Recommendationauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

Goldenseal extracts have potential as a botanical fungicide to control plant fungal diseases caused by A. panax, F. sporotrichioides and P. nanjingensis.

Taxon: goldensealHydrastis canadensise4
Interactor: A. panaxAlternaria panaxe4pathogen
Second interactor: F. sporotrichioidesFusarium sporotrichioidese4pathogen
Outcome: control plant fungal diseasese4

Verbatim

e4
“This study suggests that goldenseal extracts have the potential to be used as a botanical fungicide to control plant fungal diseases caused by A. panax, F. sporotrichioides, or P. nanjingensis”
✓ located verbatim in the source · abstract, characters 1485–1677

Title

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)

Ying Gao; Ethan Swiggart; Kaela Wolkiewicz; et al. Molecules 2024. doi:10.3390/molecules29030556

Other claims from this paper (6)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Hydrastis canadensis was recorded as a yellow dye.

Taxon: Hydrastis canadensisHydrastis canadensise0
Outcome: yellow dyee0

Verbatim

e0
“One species was described as a yellow dye (Hydrastis canadensis)”
✓ located verbatim in the source · abstract, characters 2367–2431

Title

Plants of the USA: recordings on native North American useful species by Alexander von Humboldt

Leopoldo C. Baratto; Ulrich Päßler Journal of Ethnobiology and Ethnomedicine 2024. doi:10.1186/s13002-024-00727-3

Other claims from this paper (13)

Observation The manuscript mentioned 28 species in 15 botanical families.
Observation Fagaceae was the most represented family with nine Quercus species.
Observation All identified species were USA natives except one undetermined Corylus.
Observation Four species were recorded as medicinal.
Observation Four species were recorded as tanning agents.
Observation Two species were recorded as bitter.
Observation Five Quercus species were described as the most useful for cultivation in Europe.
Observation Three Quercus species were recorded as used for ship construction.
Observation Two Quercus species were recorded as astringent.
Observation Quercus phellos was recorded as having poor quality wood.
Observation Aesculus pavia was recorded as toxic.
Observation Ten species had no useful applications listed.
Observation The manuscript lacked acknowledgment of Indigenous traditional knowledge.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Alkaloid levels increased in all colonies and samples at senescence.

Taxon: Hydrastis canadensisHydrastis canadensise0
Organ / stage: roots and rhizomese0
Outcome: alkaloid levelse2
Direction: increasee2
Setting: central Pennsylvania, USAe1

Verbatim

e0
“in wild goldenseal (Hydrastis canadensis) roots and rhizomes”
✓ located verbatim in the source · abstract, characters 84–144

e1
“Goldenseal colonies in central Pennsylvania, USA”
✓ located verbatim in the source · abstract, characters 192–240

e2
“All colonies and samples showed an increase in alkaloid levels at the time of senescence”
✓ located verbatim in the source · abstract, characters 767–855

Title

Wild Goldenseal (Hydrastis canadensis) Rhizome/Root Alkaloid Content in Relation to Colony and Harvest Stage

Eric P. Burkhart; Grady H. Zuiderveen Journal of Herbs Spices & Medicinal Plants 2019. doi:10.1080/10496475.2019.1577322

Other claims from this paper (7)

Observation Berberine and hydrastine were present in all colonies and samples.
Observation Canadine was not detected during some late season sample dates.
Observation Nineteen root samples (53%) met USP standards for berberine content.
Observation Only one sample (2.8%) met USP standards for hydrastine.
Recommendation Rhizomes/roots should be harvested at senescence.
Observation Alkaloid levels averaged the second highest at fruit maturity (July 2).
Association Alkaloids may fluctuate during the growing season in response to key reproductive events.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Berberine and hydrastine were present in all colonies and samples.

Taxon: Hydrastis canadensisHydrastis canadensise0
Outcome: berberine and hydrastine presente3

Verbatim

e0
“in wild goldenseal (Hydrastis canadensis) roots and rhizomes”
✓ located verbatim in the source · abstract, characters 84–144

e3
“berberine and hydrastine present in all colonies and samples”
✓ located verbatim in the source · abstract, characters 458–518

Title

Wild Goldenseal (Hydrastis canadensis) Rhizome/Root Alkaloid Content in Relation to Colony and Harvest Stage

Eric P. Burkhart; Grady H. Zuiderveen Journal of Herbs Spices & Medicinal Plants 2019. doi:10.1080/10496475.2019.1577322

Other claims from this paper (7)

Observation Alkaloid levels increased in all colonies and samples at senescence.
Observation Canadine was not detected during some late season sample dates.
Observation Nineteen root samples (53%) met USP standards for berberine content.
Observation Only one sample (2.8%) met USP standards for hydrastine.
Recommendation Rhizomes/roots should be harvested at senescence.
Observation Alkaloid levels averaged the second highest at fruit maturity (July 2).
Association Alkaloids may fluctuate during the growing season in response to key reproductive events.

Hydrastis canadensis 170 claims

170 claims