Abstract
Histone acetylation and deacetylation play an important role in the modification of chromatin structure and regulation of gene expression in eukaryotes. Chromatin acetylation status is modulated antagonistically by histone acetyltransferases and histone deacetylases (HDACs). In this study, we characterized the function of histone deacetylase701 (HDT701), a member of the plant-specific HD2 subfamily of HDACs, in rice (Oryza sativa) innate immunity. Transcription of HDT701 is increased in the compatible reaction and decreased in the incompatible reaction after infection by the fungal pathogen Magnaporthe oryzae. Overexpression of HDT701 in transgenic rice leads to decreased levels of histone H4 acetylation and enhanced susceptibility to the rice pathogens M. oryzae and Xanthomonas oryzae pv oryzae (Xoo). By contrast, silencing of HDT701 in transgenic rice causes elevated levels of histone H4 acetylation and elevated transcription of pattern recognition receptor (PRR) and defense-related genes, increased generation of reactive oxygen species after pathogen-associated molecular pattern elicitor treatment, as well as enhanced resistance to both M. oryzae and Xoo. We also found that HDT701 can bind to defense-related genes to regulate their expression. Taken together, these results demonstrate that HDT701 negatively regulates innate immunity by modulating the levels of histone H4 acetylation of PRR and defense-related genes in rice.
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Claims 12
Claim · model-written summary
HDT701 transcription increased in the compatible reaction after Magnaporthe oryzae infection.
- Taxon
- rice
Oryza sativat0 - Interactor
- Magnaporthe oryzae
Pyricularia oryzaee0pathogen - Gene
- HDT701e0
- Outcome
- Transcription of HDT701e0
- Direction
- increasede0
- Qualifier
- compatible reactione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Transcription of HDT701 is increased in the compatible reaction and decreased in the incompatible reaction after infection by the fungal pathogen Magnaporthe oryzae”
t0“Rice”
Claim · model-written summary
HDT701 transcription decreased in the incompatible reaction after Magnaporthe oryzae infection.
- Taxon
- riceOryza sativat0
- Interactor
- Magnaporthe oryzaePyricularia oryzaee0pathogen
- Gene
- HDT701e0
- Outcome
- Transcription of HDT701e0
- Direction
- decreasede0
- Qualifier
- incompatible reactione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Transcription of HDT701 is increased in the compatible reaction and decreased in the incompatible reaction after infection by the fungal pathogen Magnaporthe oryzae”
t0“Rice”
Claim · model-written summary
HDT701 overexpression decreased histone H4 acetylation in rice.
- Taxon
- riceOryza sativae0
- Treatment
- Overexpression of HDT701e0
- Gene
- HDT701e0
- Outcome
- levels of histone H4 acetylatione0
- Direction
- decreasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Overexpression of HDT701 in transgenic rice leads to decreased levels of histone H4 acetylation”
Claim · model-written summary
HDT701 overexpression enhanced susceptibility to Magnaporthe oryzae.
- Taxon
- riceOryza sativae0
- Treatment
- Overexpression of HDT701e0
- Interactor
- M. oryzaePyricularia oryzaee0pathogen
- Gene
- HDT701e0
- Outcome
- susceptibilitye0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Overexpression of HDT701 in transgenic rice leads to decreased levels of histone H4 acetylation and enhanced susceptibility to the rice pathogens M. oryzae and Xanthomonas oryzae pv oryzae (Xoo)”
Claim · model-written summary
HDT701 overexpression enhanced susceptibility to Xanthomonas oryzae pv oryzae.
- Taxon
- riceOryza sativat0
- Treatment
- Overexpression of HDT701e1
- Interactor
- Xanthomonas oryzae pv oryzaeXanthomonas oryzaee0pathogen
- Gene
- HDT701e1
- Outcome
- susceptibilitye0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“enhanced susceptibility to the rice pathogens M. oryzae and Xanthomonas oryzae pv oryzae (Xoo)”
t0“Rice”
e1“Overexpression of HDT701 in transgenic rice”
Claim · model-written summary
HDT701 silencing elevated histone H4 acetylation.
- Taxon
- riceOryza sativae0
- Treatment
- silencing of HDT701e0
- Gene
- HDT701e0
- Outcome
- levels of histone H4 acetylatione0
- Direction
- elevatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“silencing of HDT701 in transgenic rice causes elevated levels of histone H4 acetylation”
Claim · model-written summary
HDT701 silencing elevated transcription of PRR and defense related genes.
- Taxon
- riceOryza sativae0
- Treatment
- silencing of HDT701e0
- Gene
- HDT701e0
- Outcome
- transcription of pattern recognition receptor (PRR) and defense-related genese0
- Direction
- elevatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“silencing of HDT701 in transgenic rice causes elevated levels of histone H4 acetylation and elevated transcription of pattern recognition receptor (PRR) and defense-related genes”
Claim · model-written summary
HDT701 silencing increased reactive oxygen species generation after elicitor treatment.
- Taxon
- riceOryza sativat0
- Treatment
- silencing of HDT701e1
- Gene
- HDT701e1
- Outcome
- generation of reactive oxygen speciese0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“increased generation of reactive oxygen species after pathogen-associated molecular pattern elicitor treatment”
t0“Rice”
e1“silencing of HDT701 in transgenic rice”
Claim · model-written summary
HDT701 silencing enhanced resistance to Magnaporthe oryzae.
- Taxon
- riceOryza sativat0
- Treatment
- silencing of HDT701e1
- Interactor
- M. oryzaePyricularia oryzaee0pathogen
- Outcome
- resistancee0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“enhanced resistance to both M. oryzae and Xoo”
t0“Rice”
e1“silencing of HDT701 in transgenic rice”
Claim · model-written summary
HDT701 silencing enhanced resistance to Xoo.
- Taxon
- riceOryza sativat0
- Treatment
- silencing of HDT701e1
- Interactor
- Xooe0pathogen
- Outcome
- resistancee0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“enhanced resistance to both M. oryzae and Xoo”
t0“Rice”
e1“silencing of HDT701 in transgenic rice”
Claim · model-written summary
HDT701 bound defense related genes to regulate their expression.
- Taxon
- riceOryza sativat0
- Gene
- HDT701e0
- Outcome
- regulate their expressione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“HDT701 can bind to defense-related genes to regulate their expression”
t0“Rice”
Claim · model-written summary
The authors conclude that HDT701 negatively regulates rice innate immunity through histone H4 acetylation of defense genes.
- Taxon
- riceOryza sativae0
- Gene
- HDT701e0
- Outcome
- innate immunitye0
- Qualifier
- modulating the levels of histone H4 acetylation of PRR and defense-related genese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“HDT701 negatively regulates innate immunity by modulating the levels of histone H4 acetylation of PRR and defense-related genes in rice”
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