Claim · model-written summary
All saturated fatty acids were inactive against M. fortuitum at concentrations above 256 microg/ml.
- Taxon
- hopst0
- Interactor
- M. fortuitum
Mycolicibacterium fortuitume0pathogen - Outcome
- inactivee0
- Value
- 256 microg/mle0
Verbatim
t0“hops (Humulus lupulus)”
e0“These compounds were assessed against M. fortuitum and all saturated fatty acids were inactive at concentrations greater than 256 microg/ml”
Title
The antimycobacterial components of hops (Humulus lupulus) and their dereplication
Michael Stavri; Ruth Schneider; Gemma O'Donnell; et al. Phytotherapy Research 2004. doi:10.1002/ptr.1527
Other claims from this paper (7)
- Observation Activity of the hexane extract of hop strobiles against Mycobacterium fortuitum was associated with a low polarity fraction.
- Observation 1H NMR spectra indicated a fatty acid mixture with unsaturated components in the active hop fraction.
- Observation GC-MS of the derivatives indicated palmitic, stearic and oleic acids in the active hop fraction.
- Observation The active hop fraction contained small quantities of lignoceric, arachidic and behenic acids.
- Observation The active hop fraction contained a small quantity of linoleic acid.
- Observation The unsaturated fatty acids oleic and linoleic acid had minimum inhibitory concentrations of 4 to 16 microg/ml against the fast-growing mycobacteria tested.
- Recommendation The authors propose GC-MS of derivatised lipophilic extract components as a first dereplication step before antimycobacterial bioassay-guided studies.