By organism › Green plants › Gentianaceae › Gentiana macrophylla

Observationobservedoriginal resultsignificant (as stated)measured

Claim · model-written summary

Metabolomics identified 25,587 differentially accumulated metabolites.

Taxon: Gentiana macrophylla Pall.Gentiana macrophyllat0
Outcome: DAMse0
Value: 25,587e0
Comparator: wild and cultivatedt1

Verbatim

e0
“The metabolomics profiling revealed 25,587 DAMs (p < 0.05)”
✓ located verbatim in the source · abstract, characters 595–653

t0
“Gentiana macrophylla Pall.”
✓ located verbatim in the source · abstract, characters 12–38

t1
“wild and cultivated”
✓ located verbatim in the source · abstract, characters 565–584

Title

Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated Gentiana macrophylla Pall

Juanjuan Liu; Jialing Zhang; Yiyang Chen; et al. Metabolites 2026. doi:10.3390/metabo16030184

Other claims from this paper (5)

Observation Transcriptomics identified 6830 differentially expressed genes.
Observation Differentially expressed genes were mainly enriched in monoterpenoid and flavonoid biosynthesis.
Method / resource Six differentially expressed biosynthesis genes were validated by RT-qPCR.
Mechanism 10HGO was proposed as a key enzyme for secoiridoid biosynthesis.
Association Metabolite content and gene expression were significantly correlated.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Transcriptomics identified 6830 differentially expressed genes.

Taxon: Gentiana macrophylla Pall.Gentiana macrophyllat0
Outcome: DEGse0
Value: 6830e0
Comparator: wild and cultivatedt1

Verbatim

e0
“the transcriptomic profiling identified 6830 DEGs”
✓ located verbatim in the source · abstract, characters 660–709

t0
“Gentiana macrophylla Pall.”
✓ located verbatim in the source · abstract, characters 12–38

t1
“wild and cultivated”
✓ located verbatim in the source · abstract, characters 565–584

Title

Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated Gentiana macrophylla Pall

Juanjuan Liu; Jialing Zhang; Yiyang Chen; et al. Metabolites 2026. doi:10.3390/metabo16030184

Other claims from this paper (5)

Observation Metabolomics identified 25,587 differentially accumulated metabolites.
Observation Differentially expressed genes were mainly enriched in monoterpenoid and flavonoid biosynthesis.
Method / resource Six differentially expressed biosynthesis genes were validated by RT-qPCR.
Mechanism 10HGO was proposed as a key enzyme for secoiridoid biosynthesis.
Association Metabolite content and gene expression were significantly correlated.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Differentially expressed genes were mainly enriched in monoterpenoid and flavonoid biosynthesis.

Taxon: Gentiana macrophylla Pall.Gentiana macrophyllat0
Gene: DEGse0
Outcome: processes associated with monoterpenoid biosynthesis and flavonoid biosynthesise0

Verbatim

e0
“DEGs were predominantly enriched for processes associated with monoterpenoid biosynthesis and flavonoid biosynthesis”
✓ located verbatim in the source · abstract, characters 734–850

t0
“Gentiana macrophylla Pall.”
✓ located verbatim in the source · abstract, characters 12–38

Title

Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated Gentiana macrophylla Pall

Juanjuan Liu; Jialing Zhang; Yiyang Chen; et al. Metabolites 2026. doi:10.3390/metabo16030184

Other claims from this paper (5)

Observation Metabolomics identified 25,587 differentially accumulated metabolites.
Observation Transcriptomics identified 6830 differentially expressed genes.
Method / resource Six differentially expressed biosynthesis genes were validated by RT-qPCR.
Mechanism 10HGO was proposed as a key enzyme for secoiridoid biosynthesis.
Association Metabolite content and gene expression were significantly correlated.

Method / resourceobservedoriginal resultpositivemeasured

Claim · model-written summary

Six differentially expressed biosynthesis genes were validated by RT-qPCR.

Taxon: Gentiana macrophylla Pall.Gentiana macrophyllat0
Outcome: DEGs involved in monoterpenoid biosynthesis and flavonoid biosynthesise0
Value: sixe0

Verbatim

e0
“validated six DEGs involved in monoterpenoid biosynthesis and flavonoid biosynthesis by RT-qPCR”
✓ located verbatim in the source · abstract, characters 873–968

t0
“Gentiana macrophylla Pall.”
✓ located verbatim in the source · abstract, characters 12–38

Title

Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated Gentiana macrophylla Pall

Juanjuan Liu; Jialing Zhang; Yiyang Chen; et al. Metabolites 2026. doi:10.3390/metabo16030184

Other claims from this paper (5)

Mechanismhypothesisoriginal resultmeasured

Claim · model-written summary

10HGO was proposed as a key enzyme for secoiridoid biosynthesis.

Taxon: Gentiana macrophylla Pall.Gentiana macrophyllat0
Gene: 10HGO (8-hydroxygeraniol dehydrogenase)e0
Outcome: secoiridoid biosynthesise0

Verbatim

e0
“10HGO (8-hydroxygeraniol dehydrogenase) may be a key enzyme encoding secoiridoid biosynthesis”
✓ located verbatim in the source · abstract, characters 1006–1099

t0
“Gentiana macrophylla Pall.”
✓ located verbatim in the source · abstract, characters 12–38

Title

Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated Gentiana macrophylla Pall

Juanjuan Liu; Jialing Zhang; Yiyang Chen; et al. Metabolites 2026. doi:10.3390/metabo16030184

Other claims from this paper (5)

Observation Metabolomics identified 25,587 differentially accumulated metabolites.
Observation Transcriptomics identified 6830 differentially expressed genes.
Observation Differentially expressed genes were mainly enriched in monoterpenoid and flavonoid biosynthesis.
Method / resource Six differentially expressed biosynthesis genes were validated by RT-qPCR.
Association Metabolite content and gene expression were significantly correlated.

Associationobservedoriginal resultsignificant (as stated)measured

Claim · model-written summary

Metabolite content and gene expression were significantly correlated.

Taxon: Gentiana macrophylla Pall.Gentiana macrophyllat0
Gene: gene expressione0
Outcome: metabolite contente0

Not reportedDirection

Verbatim

e0
“significant correlation between metabolite content and gene expression”
✓ located verbatim in the source · abstract, characters 1179–1249

t0
“Gentiana macrophylla Pall.”
✓ located verbatim in the source · abstract, characters 12–38

Title

Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated Gentiana macrophylla Pall

Juanjuan Liu; Jialing Zhang; Yiyang Chen; et al. Metabolites 2026. doi:10.3390/metabo16030184

Other claims from this paper (5)

Observation Metabolomics identified 25,587 differentially accumulated metabolites.
Observation Transcriptomics identified 6830 differentially expressed genes.
Observation Differentially expressed genes were mainly enriched in monoterpenoid and flavonoid biosynthesis.
Method / resource Six differentially expressed biosynthesis genes were validated by RT-qPCR.
Mechanism 10HGO was proposed as a key enzyme for secoiridoid biosynthesis.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

The sonication extract in ethanol yielded higher total phenolics (33.12 mg/gDW) than water and methanol.

Taxon: Gentiana macrophylla PallGentiana macrophyllae0
Organ / stage: rootse0
Treatment: sonication extracte1
Outcome: total phenolicse1
Direction: highere1
Value: 33.12 mg/gDWe1
Qualifier: in ethanole1
Comparator: water and methanole1

Verbatim

e0
“quality control (QC) of roots of Gentiana macrophylla Pall”
✓ located verbatim in the source · abstract, characters 26–84

e1
“The sonication extract yielded higher amounts of total phenolics (33.12 mg/gDW) and flavonoids (17.59 mg/gDW) in ethanol compared to water and methanol”
✓ located verbatim in the source · abstract, characters 349–500

Title

Extraction and analysis of total phenolics, flavonoids and marker iridoids from Gentiana macrophylla Pall roots: a natural source of bioactive agents

Safdar Ali Amur; Safdar Ali Amur; Quratulain Khuhro; et al. Natural Product Research 2025. doi:10.1080/14786419.2025.2475511

Other claims from this paper (7)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

The sonication extract in ethanol yielded higher flavonoids (17.59 mg/gDW) than water and methanol.

Taxon: Gentiana macrophylla PallGentiana macrophyllae0
Organ / stage: rootse0
Treatment: sonication extracte1
Outcome: flavonoidse1
Direction: highere1
Value: 17.59 mg/gDWe1
Qualifier: in ethanole1
Comparator: water and methanole1

Verbatim

e0
“quality control (QC) of roots of Gentiana macrophylla Pall”
✓ located verbatim in the source · abstract, characters 26–84

e1
“The sonication extract yielded higher amounts of total phenolics (33.12 mg/gDW) and flavonoids (17.59 mg/gDW) in ethanol compared to water and methanol”
✓ located verbatim in the source · abstract, characters 349–500

Title

Extraction and analysis of total phenolics, flavonoids and marker iridoids from Gentiana macrophylla Pall roots: a natural source of bioactive agents

Safdar Ali Amur; Safdar Ali Amur; Quratulain Khuhro; et al. Natural Product Research 2025. doi:10.1080/14786419.2025.2475511

Other claims from this paper (7)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Gentiopicroside concentration in the ethanol fraction of the sonication extract was 588.48 μg/mL.

Taxon: Gentiana macrophylla PallGentiana macrophyllae0
Organ / stage: rootse0
Outcome: concentration of gentiopicrosidee2
Value: 588.48 μg/mLe2
Qualifier: in the ethanol fraction of the sonication extracte2

Verbatim

e0
“quality control (QC) of roots of Gentiana macrophylla Pall”
✓ located verbatim in the source · abstract, characters 26–84

e2
“HPLC analysis showed a high concentration of gentiopicroside (588.48 μg/mL) in the ethanol fraction of the sonication extract”
✓ located verbatim in the source · abstract, characters 502–627

Title

Extraction and analysis of total phenolics, flavonoids and marker iridoids from Gentiana macrophylla Pall roots: a natural source of bioactive agents

Safdar Ali Amur; Safdar Ali Amur; Quratulain Khuhro; et al. Natural Product Research 2025. doi:10.1080/14786419.2025.2475511

Other claims from this paper (7)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Loganic acid concentration in the water fraction was 283.58 μg/mL.

Taxon: Gentiana macrophylla PallGentiana macrophyllae0
Organ / stage: rootse0
Outcome: loganic acide3
Value: 283.58 μg/mLe3
Qualifier: in the water fractione3

Verbatim

e0
“quality control (QC) of roots of Gentiana macrophylla Pall”
✓ located verbatim in the source · abstract, characters 26–84

e3
“with loganic acid (283.58 μg/mL) and sweroside (9.49 μg/mL) in the water fraction”
✓ located verbatim in the source · abstract, characters 629–710

Title

Extraction and analysis of total phenolics, flavonoids and marker iridoids from Gentiana macrophylla Pall roots: a natural source of bioactive agents

Safdar Ali Amur; Safdar Ali Amur; Quratulain Khuhro; et al. Natural Product Research 2025. doi:10.1080/14786419.2025.2475511

Other claims from this paper (7)

Gentiana macrophylla 327 claims

327 claims