By organism › Animals › Caviidae

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

The oils relaxed isolated guinea-pig trachea with minor potency.

Taxon: guinea-pigCavia porcelluse0
Organ / stage: tracheae0
Outcome: minor potencye0

Not reportedDirection

Verbatim

e0
“and minor potency, isolated guinea-pig trachea.”
✓ located verbatim in the source · abstract, characters 1535–1582

Title

Chemical composition and pharmacological properties of the essential oils obtained seasonally fromLippia thymoides

Fabrício Souza Silva; Pedro Modesto Nascimento Menezes; Pedro Guilherme Souza de Sá; et al. Pharmaceutical Biology 2015. doi:10.3109/13880209.2015.1005751

Other claims from this paper (14)

Observation Leaf oils contain beta-caryophyllene as the major constituent at 17.22-26.27%.
Observation Leaf oils contain borneol at 4.45-7.36%.
Observation Leaf oils contain camphor at 3.22-8.61%.
Observation Leaf oils contain camphene at 2.64-5.66%.
Observation Leaf oils contain germacrene D at 4.72-6.18%.
Observation These essential oils showed no antioxidant activity in vitro.
Observation The oils were antimicrobial against Staphylococcus aureus with MIC 0.004 mg/mL.
Observation The oils had MMC 0.26-10.19 mg/mL against Staphylococcus aureus.
Observation The oils had MIC 0.03 mg/mL against Micrococcus luteus.
Observation The oils had MMC 8.43 mg/mL against Micrococcus luteus.
Observation The oils relaxed rat aorta with endothelium with EC50 305-544 μg/mL.
Observation The oils relaxed rat aorta without endothelium with EC50 150-283 μg/mL.
Observation The oils relaxed rat uterus with EC50 74-257 μg/mL.
Recommendation Lippia thymoides is a source of natural products of pharmaceutical interest and further studies are needed to identify active substances.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Leucasperone A inhibited prostaglandin-induced contractions.

Taxon: guinea pigCavia porcelluse1
Treatment: Leucasperone Ae0
Outcome: inhibition of prostaglandin-induced contractionse0

Verbatim

e0
“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
✓ located verbatim in the source · abstract, characters 598–724

e1
“guinea pig ileum”
✓ located verbatim in the source · abstract, characters 98–114

Title

Diterpenes from Leucas aspera Inhibiting Prostaglandin-Induced Contractions

Samir Kumar Sadhu; Emi Okuyama; Haruhiro Fujimoto; et al. Journal of Natural Products 2006. doi:10.1021/np058118m

Other claims from this paper (9)

Observation New leucasperones A and B were isolated from Leucas aspera.
Observation New leucasperols A and B were isolated from Leucas aspera.
Observation Three new leucasperoside glycosides were isolated.
Observation Asperphenamate, maslinic acid and (-)-isololiolide were isolated.
Observation Linifolioside was isolated.
Observation Compound structures and configurations were determined spectroscopically.
Observation Leucasperoside A inhibited prostaglandin-induced contractions.
Observation Leucasperoside B inhibited prostaglandin-induced contractions.
Observation Linifolioside inhibited prostaglandin-induced contractions.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Leucasperoside A inhibited prostaglandin-induced contractions.

Taxon: guinea pigCavia porcelluse1
Treatment: leucasperosides Ae0
Outcome: inhibition of prostaglandin-induced contractionse0

Verbatim

e0
“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
✓ located verbatim in the source · abstract, characters 598–724

e1
“guinea pig ileum”
✓ located verbatim in the source · abstract, characters 98–114

Title

Diterpenes from Leucas aspera Inhibiting Prostaglandin-Induced Contractions

Samir Kumar Sadhu; Emi Okuyama; Haruhiro Fujimoto; et al. Journal of Natural Products 2006. doi:10.1021/np058118m

Other claims from this paper (9)

Observation New leucasperones A and B were isolated from Leucas aspera.
Observation New leucasperols A and B were isolated from Leucas aspera.
Observation Three new leucasperoside glycosides were isolated.
Observation Asperphenamate, maslinic acid and (-)-isololiolide were isolated.
Observation Linifolioside was isolated.
Observation Compound structures and configurations were determined spectroscopically.
Observation Leucasperone A inhibited prostaglandin-induced contractions.
Observation Leucasperoside B inhibited prostaglandin-induced contractions.
Observation Linifolioside inhibited prostaglandin-induced contractions.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Leucasperoside B inhibited prostaglandin-induced contractions.

Taxon: guinea pigCavia porcelluse1
Treatment: Be0
Outcome: inhibition of prostaglandin-induced contractionse0

Verbatim

e0
“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
✓ located verbatim in the source · abstract, characters 598–724

e1
“guinea pig ileum”
✓ located verbatim in the source · abstract, characters 98–114

Title

Diterpenes from Leucas aspera Inhibiting Prostaglandin-Induced Contractions

Samir Kumar Sadhu; Emi Okuyama; Haruhiro Fujimoto; et al. Journal of Natural Products 2006. doi:10.1021/np058118m

Other claims from this paper (9)

Observation New leucasperones A and B were isolated from Leucas aspera.
Observation New leucasperols A and B were isolated from Leucas aspera.
Observation Three new leucasperoside glycosides were isolated.
Observation Asperphenamate, maslinic acid and (-)-isololiolide were isolated.
Observation Linifolioside was isolated.
Observation Compound structures and configurations were determined spectroscopically.
Observation Leucasperone A inhibited prostaglandin-induced contractions.
Observation Leucasperoside A inhibited prostaglandin-induced contractions.
Observation Linifolioside inhibited prostaglandin-induced contractions.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Linifolioside inhibited prostaglandin-induced contractions.

Taxon: guinea pigCavia porcelluse1
Treatment: linifoliosidee0
Outcome: inhibition of prostaglandin-induced contractionse0

Verbatim

e0
“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
✓ located verbatim in the source · abstract, characters 598–724

e1
“guinea pig ileum”
✓ located verbatim in the source · abstract, characters 98–114

Title

Diterpenes from Leucas aspera Inhibiting Prostaglandin-Induced Contractions

Samir Kumar Sadhu; Emi Okuyama; Haruhiro Fujimoto; et al. Journal of Natural Products 2006. doi:10.1021/np058118m

Other claims from this paper (9)

Observation New leucasperones A and B were isolated from Leucas aspera.
Observation New leucasperols A and B were isolated from Leucas aspera.
Observation Three new leucasperoside glycosides were isolated.
Observation Asperphenamate, maslinic acid and (-)-isololiolide were isolated.
Observation Linifolioside was isolated.
Observation Compound structures and configurations were determined spectroscopically.
Observation Leucasperone A inhibited prostaglandin-induced contractions.
Observation Leucasperoside A inhibited prostaglandin-induced contractions.
Observation Leucasperoside B inhibited prostaglandin-induced contractions.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Guinea pig antibody titers reached 1:64 twenty-one days after the third inoculation.

Taxon: guinea pigsCaviae1
Outcome: Indirect-ELISA antibody titerse0
Direction: reachede0
Value: 1:64e0
Qualifier: twenty-one days after the third inoculatione0

Verbatim

e0
“Indirect-ELISA antibody titers reached 1:64 twenty-one days after the third inoculation.”
✓ located verbatim in the source · abstract, characters 1288–1376

e1
“The immunization test in guinea pigs indicated that the expression product of transgenic tomato plants had immunogenicity and could effectively induce the specific antibodies against FMDV.”
✓ located verbatim in the source · abstract, characters 1482–1670

Title

[Protective immune response of guinea pigs against challenge with foot and mouth disease virus by immunization with foliar extracts from transgenic tomato plants expressing the FMDV structural protein VP1].

Li Pan; Yong-Guang Zhang; Yong-Lu Wang; et al. PubMed 2006

Other claims from this paper (8)

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Protection against FMDV challenge was 80% in one immunized guinea pig group.

Taxon: guinea pigsCaviae1
Outcome: protection against FMDV challengee0
Value: 80%e0
Qualifier: two groupse0

Not reportedDirection

Verbatim

e0
“In the challenge test, the protection against FMDV challenge in two groups was 80% and 40% respectively.”
✓ located verbatim in the source · abstract, characters 1377–1481

e1
“The immunization test in guinea pigs indicated that the expression product of transgenic tomato plants had immunogenicity and could effectively induce the specific antibodies against FMDV.”
✓ located verbatim in the source · abstract, characters 1482–1670

Title

[Protective immune response of guinea pigs against challenge with foot and mouth disease virus by immunization with foliar extracts from transgenic tomato plants expressing the FMDV structural protein VP1].

Li Pan; Yong-Guang Zhang; Yong-Lu Wang; et al. PubMed 2006

Other claims from this paper (8)

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Protection against FMDV challenge was 40% in the other immunized guinea pig group.

Taxon: guinea pigsCaviae1
Outcome: protection against FMDV challengee0
Value: 40%e0
Qualifier: two groupse0

Not reportedDirection

Verbatim

e0
“In the challenge test, the protection against FMDV challenge in two groups was 80% and 40% respectively.”
✓ located verbatim in the source · abstract, characters 1377–1481

e1
“The immunization test in guinea pigs indicated that the expression product of transgenic tomato plants had immunogenicity and could effectively induce the specific antibodies against FMDV.”
✓ located verbatim in the source · abstract, characters 1482–1670

Title

[Protective immune response of guinea pigs against challenge with foot and mouth disease virus by immunization with foliar extracts from transgenic tomato plants expressing the FMDV structural protein VP1].

Li Pan; Yong-Guang Zhang; Yong-Lu Wang; et al. PubMed 2006

Other claims from this paper (8)

Observationauthor interpretationoriginal resultpositivemeasured

Claim · model-written summary

The authors concluded that transgenic tomato expression products were immunogenic and could induce specific FMDV antibodies in guinea pigs.

Taxon: guinea pigsCaviae0
Outcome: had immunogenicity and could effectively induce the specific antibodies against FMDVe0

Not reportedDirection

Verbatim

e0
“The immunization test in guinea pigs indicated that the expression product of transgenic tomato plants had immunogenicity and could effectively induce the specific antibodies against FMDV.”
✓ located verbatim in the source · abstract, characters 1482–1670

Title

[Protective immune response of guinea pigs against challenge with foot and mouth disease virus by immunization with foliar extracts from transgenic tomato plants expressing the FMDV structural protein VP1].

Li Pan; Yong-Guang Zhang; Yong-Lu Wang; et al. PubMed 2006

Other claims from this paper (8)

Method / resource A plant VP1 expression vector was successfully constructed.
Method / resource Sixty resistant transformed tomato lines were obtained after selection.
Observation Integration and transcription of VP1 in transformed tomato plants were confirmed.
Observation About 40% of transformed plants expressed the recombinant protein.
Observation Plant-expressed FMDV VP1 was specifically recognized by polyclonal antibodies against FMDV.
Observation Guinea pig antibody titers reached 1:64 twenty-one days after the third inoculation.
Observation Protection against FMDV challenge was 80% in one immunized guinea pig group.
Observation Protection against FMDV challenge was 40% in the other immunized guinea pig group.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

The extract produced guinea pig ileum contractions blocked by atropine.

Taxon: guinea pigCavia porcelluse0
Organ / stage: smooth musclee0
Treatment: extracte0
Outcome: contractionse0
Qualifier: blocked by atropinee0

Not reportedComparatorDirection

Verbatim

e0
“On smooth muscle of guinea pig ileum, the extract produced contractions which was blocked by atropine supporting its use in constipation.”
✓ located verbatim in the source · abstract, characters 592–729

Title

Pharmacological Studies on Aerial Parts of Calotropis Procera

J. S. Mossa; M. Tariq; A. Mohsin; et al. The American Journal of Chinese Medicine 1991. doi:10.1142/s0192415x91000302

Other claims from this paper (6)

Intervention effect Calotropis extract had significant antipyretic, analgesic and neuromuscular blocking activity in laboratory animals.
Intervention effect The extract did not produce significant anti-inflammatory or antibacterial activity.
Observation C. procera aerial parts contained alkaloids, cardiac glycosides and tannins.
Observation C. procera aerial parts contained flavonoids and sterols and/or triterpenes.
Intervention effect Single extract doses up to 3 g/kg produced no visible toxic symptoms or mortality.
Intervention effect Treatment for 90 days caused significantly higher mortality than controls.

Caviidae 10 claims

10 claims