Claim · model-written summary
Silencing of Cbl10 and Cipk6 in Nicotiana benthamiana inhibited Pto/AvrPto-elicited programmed cell death.
- Taxon
- Nicotiana benthamiana
Nicotiana benthamianae1 - Treatment
- virus-induced gene silencinge1
- Gene
- Cbl10e1
- Outcome
- Pto/AvrPto-elicited PCDe1
- Direction
- inhibitede1
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“In a virus-induced gene silencing screen in Nicotiana benthamiana, we independently identified two components of a Ca(2+)-signaling system, Cbl10 (for calcineurin B-like protein) and Cipk6 (for calcineurin B-like interacting protein kinase), as their silencing inhibited Pto/AvrPto-elicited PCD”
Title
F. de la Torre; E. Gutierrez-Beltran; Y. Pareja-Jaime; et al. The Plant Cell 2013. doi:10.1105/tpc.113.113530
Other claims from this paper (11)
- Observation Cbl10 and Cipk6 are required for programmed cell death triggered by other plant resistance genes.
- Observation Cbl10 and Cipk6 are required for programmed cell death triggered by virus effectors.
- Observation Cbl10 and Cipk6 are required for programmed cell death triggered by oomycete effectors.
- Observation Cbl10 and Cipk6 are required for programmed cell death triggered by nematode effectors.
- Observation Cbl10 and Cipk6 are required for host susceptibility to P. syringae.
- Observation Tomato Cipk6 interacts with Cbl10.
- Observation The in vitro kinase activity of tomato Cipk6 is enhanced in the presence of Cbl10 and Ca2+.
- Intervention effect Overexpression of tomato Cipk6 in N. benthamiana causes accumulation of reactive oxygen species.
- Mechanism The accumulation of reactive oxygen species requires RbohB.
- Observation Tomato Cbl10 and Cipk6 interact with RbohB at the plasma membrane.
- Observation Cbl10 and Cipk6 contribute to ROS generated during effector-triggered immunity in the interaction of P. syringae pv tomato DC3000 with N. benthamiana.